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IPR016685 is a RNA-induced silencing complex, nuclease component Tudor-SN.
<p>This entry represents the Tudor staphylococcal nuclease (Tudor-SN) subunit of the RNA-induced silencing complex (RISC) [[cite:PUB00042723], [cite:PUB00042725]]. RISC is central to the mechanism of RNA interference (RNAi), which is triggered by the presence of dsRNA, resulting in silencing of the cognate gene. In RNAi, dsRNA is processed by RNase III ribonucleases (from Dicer family) to yield small interfering RNAs (siRNAs), which are unwound and incorporated into the RISC ribonucleoprotein complex that ultimately targets the cognate mRNA. Various components of the RISC have been identified that are highly conserved between species. In Drosophila melanogaster (Fruit fly) these subunits include the proteins Argonaute2, VIG, FXR and Tudor-SN. Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | RISC complex | A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. | ||
| Biological process | Gene silencing by RNA | Any process in which RNA molecules inactivate expression of target genes. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: staphylococcal nuclease domain-containing protein 1-like [Glycine max] gi|356516458|ref|XP_003526911.1| | 19 | ||
| – | PREDICTED: staphylococcal nuclease domain-containing protein 1-like [Glycine max] gi|356508886|ref|XP_003523184.1| | 7 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331200 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331200 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400 | 19 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400 | 20 | ||
| – | Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KP14|I1KP14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0416800 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.69 |