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IPR017151 is a 5'-3' exoribonuclease type 2.
<p>5'-3'-exoribonucleases are enzymes that degrade RNA by removing terminal nucleotides from the 5' end. Hydrolytic exoribonucleases, to which this entry belongs, produce nucleotide monosphosphates. An exosome and a 5'-3'-exoribonuclease are important in the degradation of very unstable transcripts [[cite:PUB00043318]].</p> <p>This entry includes 5'-3'exoribonuclease type 2 (Xrn2, also known as Rat1), which occurs in animal, plant and fungal lineages. They act as post-transcriptional gene silencing (PTGS) suppressors [[cite:PUB00073457]]. In Saccharomyces cerevisiae, Rat1 serves to terminate RNA polymerase II (RNAPII) molecules engaged in the production of uncapped RNA [[cite:PUB00063330]]. This entry also includes plant Xrn3 and Xrn4.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 5'-3' exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | Nucleobase-containing compound metabolic process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 5'-3' exoribonuclease 3-like [Glycine max] gi|356562399|ref|XP_003549459.1| | 15 | ||
| – | PREDICTED: 5'-3' exoribonuclease 3-like [Glycine max] gi|356562399|ref|XP_003549459.1| | 15 | ||
| – | 5'-3' exoribonuclease; TAIR: AT1G54490.1 exoribonuclease 4; Swiss-Prot: sp|Q9FQ04|XRN4_ARATH 5'-3' exoribonuclease 4; TrEMBL-Plants: tr|I1JRL0|I1JRL0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0778800 | 19 | ||
| – | 5'-3' exoribonuclease 3; TAIR: AT1G75660.1 5'-3' exoribonuclease 3; Swiss-Prot: sp|Q9FQ03|XRN3_ARATH 5'-3' exoribonuclease 3; TrEMBL-Plants: tr|V7AFU3|V7AFU3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0472700 | 13 | ||
| – | 5'-3' exoribonuclease; TAIR: AT1G75660.1 5'-3' exoribonuclease 3; Swiss-Prot: sp|Q9FQ03|XRN3_ARATH 5'-3' exoribonuclease 3; TrEMBL-Plants: tr|V7AFU3|V7AFU3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0472700 | 13 | ||
| – | 5'-3' exoribonuclease 3; TAIR: AT1G75660.1 5'-3' exoribonuclease 3; Swiss-Prot: sp|Q9FQ03|XRN3_ARATH 5'-3' exoribonuclease 3; TrEMBL-Plants: tr|I1MY22|I1MY22_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0007100 | 20 | ||
| – | 5'-3' exoribonuclease 3; TAIR: AT1G75660.1 5'-3' exoribonuclease 3; Swiss-Prot: sp|Q9FQ03|XRN3_ARATH 5'-3' exoribonuclease 3; TrEMBL-Plants: tr|A0A0B2PTI7|A0A0B2PTI7_GLYSO 5'-3' exoribonuclease 3; Found in the gene: LotjaGi5g1v0007100 | 20 | ||
| – | 5'-3' exoribonuclease; TAIR: AT1G54490.2 exoribonuclease 4; Swiss-Prot: sp|Q9FQ04|XRN4_ARATH 5'-3' exoribonuclease 4; TrEMBL-Plants: tr|I1NIU3|I1NIU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0214900 | 19 | ||
| – | 5'-3' exoribonuclease; TAIR: AT1G54490.1 exoribonuclease 4; Swiss-Prot: sp|Q9FQ04|XRN4_ARATH 5'-3' exoribonuclease 4; TrEMBL-Plants: tr|I1NIU3|I1NIU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0214900 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |