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IPR018484 is a Carbohydrate kinase FGGY, N-terminal.
<p>This entry represents the N-terminal domain of these proteins. It adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain [[cite:PUB00005161], [cite:PUB00019551]].</p> <p>FGGY carbohydrate kinases carry out ATP-dependent phosphorylation on one out of at least nine distinct sugar substrates [[cite:PUB00080793]]. These enzymes include L-ribulokinase ([ec:2.7.1.16]) (gene araB); Erythriol kinase ([ec:2.7.1.27]) (gene eryA); L-fucolokinase ([ec:2.7.1.51]) (gene fucK); gluconokinase ([ec:2.7.1.12]) (gene gntK); glycerol kinase ([ec:2.7.1.30]) (gene glpK); xylulokinase ([ec:2.7.1.17]) (gene xylB); L-xylulose kinase ([ec:2.7.1.53]) (gene lyxK), D-ribulokinase ([ec:2.7.1.47]) (gene rbtK); and rhamnulokinase ([ec:2.7.1.5]) (gene rhaB). This family also contains a divergent subfamily functioning in quorum sensing, which phosphorylates AI-2, a bacterial signaling molecule derived from 4,5-dihydroxy-2,3-pentanedione (DPD) [[cite:PUB00056209]].</p> <p>All described members of this enzyme family are composed of two homologous actin-like ATPase domains. A catalytic cleft is formed by the interface between these two domains, where the sugar substrate and ATP co-substrate bind.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. | ||
| Molecular function | Phosphotransferase activity, alcohol group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: xylulose kinase-like [Glycine max] gi|356507959|ref|XP_003522730.1| | 11 | ||
| – | PREDICTED: xylulose kinase-like [Glycine max] gi|356507959|ref|XP_003522730.1| | 6 | ||
| – | Xylulose kinase [Medicago truncatula] gi|357466769|ref|XP_003603669.1| | 9 | ||
| – | Actin-like ATPase superfamily protein isoform 3 [Theobroma cacao] gi|508778662|gb|EOY25918.1| | 6 | ||
| – | Glycerol kinase [Medicago truncatula] gi|357468137|ref|XP_003604353.1| | 15 | ||
| – | 10 | |||
| – | PREDICTED: xylulose kinase-like [Glycine max] gi|356538722|ref|XP_003537850.1| | 10 | ||
| – | Xylulose kinase-like protein; TAIR: AT5G49650.1 xylulose kinase-2; Swiss-Prot: sp|Q5R830|XYLB_PONAB Xylulose kinase; TrEMBL-Plants: tr|I3SF17|I3SF17_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0412400 | 13 | ||
| – | Glycerol kinase; TAIR: AT1G80460.1 Actin-like ATPase superfamily protein; Swiss-Prot: sp|Q9M8L4|GLPK_ARATH Glycerol kinase; TrEMBL-Plants: tr|I1KGY8|I1KGY8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0354100_LC | 11 | ||
| – | Glycerol kinase-like protein; TAIR: AT1G80460.1 Actin-like ATPase superfamily protein; Swiss-Prot: sp|Q9M8L4|GLPK_ARATH Glycerol kinase; TrEMBL-Plants: tr|G7JGV7|G7JGV7_MEDTR Glycerol kinase-like protein; Found in the gene: LotjaGi3g1v0354200 | 16 | ||
| – | Glycerol kinase; TAIR: AT2G21370.1 xylulose kinase-1; Swiss-Prot: sp|P27155|XYLB_STAXY Xylulose kinase; TrEMBL-Plants: tr|K7LP67|K7LP67_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0513400 | 11 | ||
| – | Glycerol kinase; TAIR: AT4G30310.2 FGGY family of carbohydrate kinase; Swiss-Prot: sp|Q6DCD1|FGGY_XENLA FGGY carbohydrate kinase domain-containing protein; TrEMBL-Plants: tr|A0A1J7GZV6|A0A1J7GZV6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0298300 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07782 | CDD | 1 | 8.33 |