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IPR025260 is a Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain.
<p>This entry represents a domain found at the C terminus of chromodomain-helicase-DNA-binding proteins, including Chromodomain-helicase-DNA-binding protein 1 from human (CHD1), an ATP-dependent chromatin-remodeling factor which acts as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. This protein functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 [[cite:PUB00100856], [cite:PUB00100857]]. This helical domain, which is also found in CHD1 helical C-terminal domain-containing protein 1 (also known as C17orf64) from mammals [[cite:PUB00101868]], consists of five α-helices organised in a variant helical bundle topology. Its surface is positively charged and can bind dsDNA and nucleosomes, but its specific function remains unknown [[cite:PUB00091268]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: chromodomain-helicase-DNA-binding protein 2-like [Glycine max] gi|356554106|ref|XP_003545390.1| | 21 | ||
| – | Chromodomain helicase-DNA-binding protein; TAIR: AT2G13370.1 chromatin remodeling 5; Swiss-Prot: sp|F4IV99|CHR5_ARATH Protein CHROMATIN REMODELING 5; TrEMBL-Plants: tr|I1JIZ0|I1JIZ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0048100 | 34 | ||
| – | Chromodomain helicase-DNA-binding protein; TAIR: AT2G13370.1 chromatin remodeling 5; Swiss-Prot: sp|F4IV99|CHR5_ARATH Protein CHROMATIN REMODELING 5; TrEMBL-Plants: tr|I1JIZ0|I1JIZ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0048100 | 34 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |