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IPR026300 is a CWF11 family.
<p>This family includes Aquarius, which is a pre-mRNA splicing factor and has RNA helicase activity. It is responsible for coupling snoRNP (small nucleolar ribonucleoprotein) assembly to intron excision [[cite:PUB00056687]]. Aquarius also contributes to the maintenance of genomic stability via regulation of homologous recombination by CtIP-dependent and -independent pathways [[cite:PUB00088394]]. This family also includes pre-mRNA-splicing factor cwf11, which associates with cdc5 and the other cwf proteins as part of the spliceosome and is involved in mRNA splicing [[cite:PUB00008533]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | MRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. | ||
| Cellular component | Spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: intron-binding protein aquarius-like [Glycine max] gi|356574068|ref|XP_003555174.1| | 14 | ||
| – | Embryo defective 2765; TAIR: AT2G38770.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O60306|AQR_HUMAN Intron-binding protein aquarius; TrEMBL-Plants: tr|I1NCV6|I1NCV6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0024500 | 16 | ||
| – | Embryo defective 2765; TAIR: AT2G38770.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O60306|AQR_HUMAN Intron-binding protein aquarius; TrEMBL-Plants: tr|I1NCV6|I1NCV6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0024500 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18808 | CDD | 1 | 33.33 |