Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR031645 is a Vacuolar protein sorting-associated protein 13, DH-like domain.
<p>This entry represents a domain reminiscent of a DH domain (DH-like domain) found adjacent the predicted C-terminal PH-like domain of VPS13 proteins [[cite:PUB00100769], [cite:PUB00061937], [cite:PUB00075977], [cite:PUB00100863]]. DHL-PH domains has been identified as the mitochondria-binding region of VPS13A and the lipid droplet-binding region of both proteins. These two domains contain a region of high similarity to ATG2, which also binds lipid droplets [[cite:PUB00100769], [cite:PUB00100863]].</p> <p>VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [[cite:PUB00100726], [cite:PUB00100766], [cite:PUB00100863]]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [[cite:PUB00100863], [cite:PUB00100766], [cite:PUB00100768]]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [[cite:PUB00100501], [cite:PUB00100769]]. Members of this entry belong to the repeating β-groove (RBG) superfamily. These proteins share a structure made of multiple repeating modules consisting of five β-sheets followed by a loop [[cite:PUB00101861]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | C-5 cytosine-specific DNA methylase; Vacuolar protein sorting-associated protein [Medicago truncatula] gi|124360290|gb|ABN08303.1| | 8 | ||
| – | Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357445545|ref|XP_003593050.1| | 8 | ||
| – | Os12g0594200 [Oryza sativa Japonica Group] gi|297613455|ref|NP_001067177.2| | 7 | ||
| – | Os12g0594200 [Oryza sativa Japonica Group] gi|297613455|ref|NP_001067177.2| | 7 | ||
| – | PREDICTED: vacuolar protein sorting-associated protein 13A-like isoform X4 [Cicer arietinum] gi|502170055|ref|XP_004514747.1| | 5 | ||
| – | Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357445545|ref|XP_003593050.1| | 5 | ||
| – | 5 | |||
| – | Vacuolar protein sorting-associated protein, putative; TAIR: AT5G24740.2 vacuolar protein sorting-associated protein, putative (DUF1162); Swiss-Prot: sp|Q54LB8|VP13A_DICDI Putative vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|G7IJW3|G7IJW3_MEDTR Vacuolar protein sorting-associated protein, putative; Found in the gene: LotjaGi1g1v0116300 | 15 | ||
| – | Vacuolar protein sorting-associated protein, putative; TAIR: AT5G24740.2 vacuolar protein sorting-associated protein, putative (DUF1162); Swiss-Prot: sp|Q54LB8|VP13A_DICDI Putative vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|G7IJW3|G7IJW3_MEDTR Vacuolar protein sorting-associated protein, putative; Found in the gene: LotjaGi4g1v0279000 | 15 | ||
| – | Calcium-dependent lipid-binding family protein isoform protein; TAIR: AT1G48090.4 calcium-dependent lipid-binding family protein; Swiss-Prot: sp|Q54LB8|VP13A_DICDI Putative vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|A0A072V2R4|A0A072V2R4_MEDTR Calcium-dependent lipid-binding-like protein; Found in the gene: LotjaGi4g1v0334900 | 28 | ||
| – | Calcium-dependent lipid-binding family protein isoform protein; TAIR: AT1G48090.4 calcium-dependent lipid-binding family protein; Swiss-Prot: sp|Q709C8|VP13C_HUMAN Vacuolar protein sorting-associated protein 13C; TrEMBL-Plants: tr|A0A072V2R4|A0A072V2R4_MEDTR Calcium-dependent lipid-binding-like protein; Found in the gene: LotjaGi4g1v0334900 | 26 | ||
| – | Calcium-dependent lipid-binding family protein isoform protein; TAIR: AT1G48090.4 calcium-dependent lipid-binding family protein; Swiss-Prot: sp|Q709C8|VP13C_HUMAN Vacuolar protein sorting-associated protein 13C; TrEMBL-Plants: tr|A0A072V2R4|A0A072V2R4_MEDTR Calcium-dependent lipid-binding-like protein; Found in the gene: LotjaGi4g1v0334900 | 26 | ||
| – | Calcium-dependent lipid-binding family protein isoform protein; TAIR: AT1G48090.4 calcium-dependent lipid-binding family protein; Swiss-Prot: sp|Q54LB8|VP13A_DICDI Putative vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|A0A072V2R4|A0A072V2R4_MEDTR Calcium-dependent lipid-binding-like protein; Found in the gene: LotjaGi4g1v0334900 | 28 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.69 |