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IPR027131 is a Structural maintenance of chromosomes protein 5.
<p>SMC5 is a core component of the SMC5-SMC6 complex [[cite:PUB00020587], [cite:PUB00063405]], a complex involved in repair of DNA double-strand breaks by homologous recombination [[cite:PUB00062987], [cite:PUB00062988]]. In humans, the SMC5-SMC6 complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks [[cite:PUB00062326]]. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) [[cite:PUB00062327]]. SMC5 is required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 [[cite:PUB00061931]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Biological process | Sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. | ||
| Cellular component | Smc5-Smc6 complex | A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: structural maintenance of chromosomes protein 5-like [Glycine max] gi|356576425|ref|XP_003556332.1| | 11 | ||
| – | PREDICTED: structural maintenance of chromosomes protein 5-like [Glycine max] gi|356576425|ref|XP_003556332.1| | 11 | ||
| – | PREDICTED: structural maintenance of chromosomes protein 5-like [Glycine max] gi|356576425|ref|XP_003556332.1| | 12 | ||
| – | Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|A0A151TWB4|A0A151TWB4_CAJCA Structural maintenance of chromosomes protein 5; Found in the gene: LotjaGi3g1v0119400_LC | 6 | ||
| – | Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|A0A0S3QXY9|A0A0S3QXY9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0119400_LC | 7 | ||
| – | Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|G7JE71|G7JE71_MEDTR Structural maintenance-like chromosomes-protein; Found in the gene: LotjaGi3g1v0119400_LC | 6 | ||
| – | Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|G7J0X6|G7J0X6_MEDTR Structural maintenance-like chromosomes-protein; Found in the gene: LotjaGi3g1v0119500_LC | 9 | ||
| – | Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|V7CP68|V7CP68_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0119700 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03277 | CDD | 1 | 12.50 |