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IPR031047 is a DNA helicase INO80, DEAQ-box helicase domain.
<p>Ino80 is evolutionarily conserved from yeast to human [[cite:PUB00062156]]. It is an ATPase subunit of the INO80 complex [[cite:PUB00052593]]. The Ino80 complex displays 3'-5' DNA helicase activity and is involved in transcription, DNA replication and repair, and chromatin remodelling [[cite:PUB00074372], [cite:PUB00061630], [cite:PUB00074373]]. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1 [[cite:PUB00101637]]. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status [[cite:PUB00101636]]. INO80 is a member of the DEAD-like helicase superfamily.</p> <p>This domain contains the ATP-binding region of INO80 from fungi and animals.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Biological process | Chromatin remodeling | Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. | ||
| Biological process | Transcription, DNA-templated | The cellular synthesis of RNA on a template of DNA. | ||
| Molecular function | ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. | ||
| Cellular component | Ino80 complex | A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA helicase INO80; TAIR: AT3G57300.1 DNA helicase INO80-like protein; Swiss-Prot: sp|Q8RXS6|INO80_ARATH DNA helicase INO80; TrEMBL-Plants: tr|I1N8X6|I1N8X6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0670100 | 24 | ||
| – | DNA helicase INO80; TAIR: AT3G57300.1 DNA helicase INO80-like protein; Swiss-Prot: sp|Q8RXS6|INO80_ARATH DNA helicase INO80; TrEMBL-Plants: tr|I1N8X6|I1N8X6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0670100 | 24 | ||
| – | DNA helicase; TAIR: AT3G57300.1 DNA helicase INO80-like protein; Swiss-Prot: sp|Q8RXS6|INO80_ARATH DNA helicase INO80; TrEMBL-Plants: tr|I1N8X6|I1N8X6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0670100 | 24 | ||
| – | DNA helicase; TAIR: AT3G57300.1 DNA helicase INO80-like protein; Swiss-Prot: sp|Q8RXS6|INO80_ARATH DNA helicase INO80; TrEMBL-Plants: tr|I1N8X6|I1N8X6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0670100 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |