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IPR031968 is a VASt domain.
<p>The VASt (VAD1 Analog of StAR-related lipid transfer) domain is conserved across eukaryotes and is structurally related to Bet v1-like domains, including START lipid-binding domains. The ~190-amino acid VASt domain is predominantly associated with lipid binding domains such as GRAM, C2 and PH domains. The VASt domain is likely to have a function in binding large hydrophobic ligands and may be specific for sterol [[cite:PUB00084279], [cite:PUB00084280]].</p> <p>The predicted structure of the VASt domain is a two-layer sandwich α/β fold, also called "helix grip fold", containing three α-helices (α1 to 3), six β-sheets (β1 to 6) and two loops (ω1 and 2) numbered from N to C terminus [[cite:PUB00084279]].</p> <p>Some proteins known to contain a VASt domain are listed below:</p> <ul> <li>Plant vascular associated death1 (VAD1), a regulator of programmed cell death (PCD) harboring a GRAM putative lipid-binding domain.</li> <li>Yeast SNF1 Interacting Protein 3 (SIP3), may be involved in sterol transfer between intracellular membranes.</li> <li>Yeast Suicide Protein 1 (YSP1), a mitochondrial protein specifically required for the mitochondrial thread-grain transition, de-energization, and the cell death. May be involved in sterol transfer between intracellular membranes.</li> <li>Yeast Suicide Protein 2 (YSP2), a mitochondrial membrane protein involved in mitochondrial fragmentation. May be involved in sterol transfer between intracellular membranes.</li> <li>Human GramD1a-c.</li> </ul>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: C2 and GRAM domain-containing protein At1g03370-like [Glycine max] gi|356500100|ref|XP_003518872.1| | 5 | ||
| – | PREDICTED: GRAM domain-containing protein 1C-like isoform X4 [Cicer arietinum] gi|502173547|ref|XP_004515355.1| | 9 | ||
| – | PREDICTED: GRAM domain-containing protein 1C-like isoform X4 [Cicer arietinum] gi|502173547|ref|XP_004515355.1| | 9 | ||
| – | PREDICTED: C2 and GRAM domain-containing protein At1g03370-like [Cicer arietinum] gi|502142930|ref|XP_004505156.1| | 18 | ||
| – | PREDICTED: C2 and GRAM domain-containing protein At1g03370-like [Glycine max] gi|356532855|ref|XP_003534985.1| | 19 | ||
| – | C2 and GRAM domain-containing protein; TAIR: AT5G50170.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9FGS8|C2GR2_ARATH C2 and GRAM domain-containing protein At5g50170; TrEMBL-Plants: tr|A0A0R0K9Z2|A0A0R0K9Z2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0196800 | 21 | ||
| – | C2 and GRAM domain-containing protein; TAIR: AT5G50170.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9FGS8|C2GR2_ARATH C2 and GRAM domain-containing protein At5g50170; TrEMBL-Plants: tr|A0A0R0K9Z2|A0A0R0K9Z2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0196800 | 21 | ||
| – | GRAM domain family protein; TAIR: AT1G02120.1 GRAM domain family protein; Swiss-Prot: sp|F4HVW5|VAD1_ARATH Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; TrEMBL-Plants: tr|A0A072TWG7|A0A072TWG7_MEDTR PH-GRAM1-TCB1D9-TCB1D9B domain protein; Found in the gene: LotjaGi3g1v0067300 | 16 | ||
| – | GRAM domain family protein; TAIR: AT1G02120.1 GRAM domain family protein; Swiss-Prot: sp|F4HVW5|VAD1_ARATH Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; TrEMBL-Plants: tr|A0A072TJX9|A0A072TJX9_MEDTR PH-GRAM1-TCB1D9-TCB1D9B domain protein; Found in the gene: LotjaGi3g1v0067300 | 16 | ||
| – | GRAM domain family protein; TAIR: AT1G02120.1 GRAM domain family protein; Swiss-Prot: sp|F4HVW5|VAD1_ARATH Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; TrEMBL-Plants: tr|A0A072TJX9|A0A072TJX9_MEDTR PH-GRAM1-TCB1D9-TCB1D9B domain protein; Found in the gene: LotjaGi3g1v0067300 | 16 | ||
| – | GRAM domain family protein; TAIR: AT1G02120.1 GRAM domain family protein; Swiss-Prot: sp|F4HVW5|VAD1_ARATH Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; TrEMBL-Plants: tr|A0A072TWG7|A0A072TWG7_MEDTR PH-GRAM1-TCB1D9-TCB1D9B domain protein; Found in the gene: LotjaGi3g1v0067300 | 16 | ||
| – | C2 and GRAM domain-containing protein; TAIR: AT1G03370.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9ZVT9|C2GR1_ARATH C2 and GRAM domain-containing protein At1g03370; TrEMBL-Plants: tr|I1KNM4|I1KNM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0005000 | 24 | ||
| – | C2 and GRAM domain-containing protein; TAIR: AT1G03370.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9ZVT9|C2GR1_ARATH C2 and GRAM domain-containing protein At1g03370; TrEMBL-Plants: tr|I1KNM4|I1KNM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0005000 | 24 | ||
| – | C2 domain-containing protein / GRAM domain-containing protein; TAIR: AT3G59660.1 C2 domain-containing protein / GRAM domain-containing protein; Swiss-Prot: sp|Q8W4D4|BAGP1_ARATH BAG-associated GRAM protein 1; TrEMBL-Plants: tr|K7K882|K7K882_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0068800 | 28 | ||
| – | C2 domain-containing protein / GRAM domain-containing protein; TAIR: AT3G59660.1 C2 domain-containing protein / GRAM domain-containing protein; Swiss-Prot: sp|Q8W4D4|BAGP1_ARATH BAG-associated GRAM protein 1; TrEMBL-Plants: tr|K7K881|K7K881_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0068800 | 20 | ||
| – | C2 domain-containing protein / GRAM domain-containing protein; TAIR: AT3G59660.1 C2 domain-containing protein / GRAM domain-containing protein; Swiss-Prot: sp|Q8W4D4|BAGP1_ARATH BAG-associated GRAM protein 1; TrEMBL-Plants: tr|K7K882|K7K882_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0068800 | 20 | ||
| – | C2 and GRAM domain-containing protein; TAIR: AT1G03370.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9ZVT9|C2GR1_ARATH C2 and GRAM domain-containing protein At1g03370; TrEMBL-Plants: tr|A0A0B2S6D4|A0A0B2S6D4_GLYSO C2 and GRAM domain-containing protein; Found in the gene: LotjaGi6g1v0281500 | 24 | ||
| – | C2 and GRAM domain-containing protein; TAIR: AT1G03370.2 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9ZVT9|C2GR1_ARATH C2 and GRAM domain-containing protein At1g03370; TrEMBL-Plants: tr|A0A0B2S6D4|A0A0B2S6D4_GLYSO C2 and GRAM domain-containing protein; Found in the gene: LotjaGi6g1v0281500 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 5.56 |