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IPR033655

Source: InterPro

Description

IPR033655 is a RelA/SpoT, TGS domain.

<p>RelA/SpoT homologue (RSH) proteins play a central role in bacterial stringent response. RelA (also referred to as ppGpp hydrolase/synthetase) and SpoT are activated during stress conditions and synthesize transcriptional modulators (p)ppGpp that allow bacteria to adapt to this condicions. They contain a TGS domain, named after the Threonyl-tRNA Synthetase, GTPase, and SpoT proteins where it occurs [[cite:PUB00079753]]. This domain of RelA binds the CCA tail to orient the free 3' hydroxyl group of the terminal adenosine towards a β-strand, thus an aminoacylated tRNA at this position would be sterically impeded. This association suppresses auto-inhibition and activates the synthesis of (p)ppGpp and initiates the stringent response. [[cite:PUB00095793], [cite:PUB00095792]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 11

Transcript Name Description Predicted domains Domain count
Lj1g3v4875630.1
– PREDICTED: GTP pyrophosphokinase-like isoform X1 [Cicer arietinum] gi|502112635|ref|XP_004494394.1|
Domains
25
LotjaGi1g1v0763000.1
– GTP pyrophosphokinase; TAIR: AT4G02260.2 RELA/SPOT homolog 1; Swiss-Prot: sp|P0DKG8|RSH1L_ARATH Putative GTP diphosphokinase RSH1, chloroplastic; TrEMBL-Plants: tr|A0A0B2QGP0|A0A0B2QGP0_GLYSO GTP pyrophosphokinase; Found in the gene: LotjaGi1g1v0763000
Domains
31
LotjaGi1g1v0763000.2
– GTP pyrophosphokinase; TAIR: AT4G02260.2 RELA/SPOT homolog 1; Swiss-Prot: sp|P0DKG8|RSH1L_ARATH Putative GTP diphosphokinase RSH1, chloroplastic; TrEMBL-Plants: tr|A0A0B2QGP0|A0A0B2QGP0_GLYSO GTP pyrophosphokinase; Found in the gene: LotjaGi1g1v0763000
Domains
32
LotjaGi1g1v0763000.3
– GTP pyrophosphokinase; TAIR: AT4G02260.2 RELA/SPOT homolog 1; Swiss-Prot: sp|P0DKG8|RSH1L_ARATH Putative GTP diphosphokinase RSH1, chloroplastic; TrEMBL-Plants: tr|A0A0B2QGP0|A0A0B2QGP0_GLYSO GTP pyrophosphokinase; Found in the gene: LotjaGi1g1v0763000
Domains
32
LotjaGi1g1v0763000.4
– GTP pyrophosphokinase; TAIR: AT4G02260.2 RELA/SPOT homolog 1; Swiss-Prot: sp|P0DKG8|RSH1L_ARATH Putative GTP diphosphokinase RSH1, chloroplastic; TrEMBL-Plants: tr|A0A0B2QGP0|A0A0B2QGP0_GLYSO GTP pyrophosphokinase; Found in the gene: LotjaGi1g1v0763000
Domains
31
LotjaGi2g1v0448600.1
– Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; TAIR: AT1G54130.1 RELA/SPOT homolog 3; Swiss-Prot: sp|Q9SYH1|RSH3C_ARATH Probable GTP diphosphokinase RSH3, chloroplastic; TrEMBL-Plants: tr|A0A0B2R105|A0A0B2R105_GLYSO Putative GTP pyrophosphokinase; Found in the gene: LotjaGi2g1v0448600
Domains
22
LotjaGi2g1v0448600.2
– Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; TAIR: AT1G54130.1 RELA/SPOT homolog 3; Swiss-Prot: sp|Q9SYH1|RSH3C_ARATH Probable GTP diphosphokinase RSH3, chloroplastic; TrEMBL-Plants: tr|A0A0B2R105|A0A0B2R105_GLYSO Putative GTP pyrophosphokinase; Found in the gene: LotjaGi2g1v0448600
Domains
22
LotjaGi2g1v0448600.3
– Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; TAIR: AT1G54130.1 RELA/SPOT homolog 3; Swiss-Prot: sp|Q9SYH1|RSH3C_ARATH Probable GTP diphosphokinase RSH3, chloroplastic; TrEMBL-Plants: tr|A0A0R0HH22|A0A0R0HH22_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0448600
Domains
22
LotjaGi2g1v0448600.4
– Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; TAIR: AT1G54130.1 RELA/SPOT homolog 3; Swiss-Prot: sp|Q9SYH1|RSH3C_ARATH Probable GTP diphosphokinase RSH3, chloroplastic; TrEMBL-Plants: tr|A0A0R0LJ13|A0A0R0LJ13_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0448600
Domains
22
LotjaGi2g1v0448600.5
– Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; TAIR: AT1G54130.1 RELA/SPOT homolog 3; Swiss-Prot: sp|Q9SYH1|RSH3C_ARATH Probable GTP diphosphokinase RSH3, chloroplastic; TrEMBL-Plants: tr|A0A0R0LJ13|A0A0R0LJ13_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0448600
Domains
22
LotjaGi2g1v0448600.6
– Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; TAIR: AT1G54130.1 RELA/SPOT homolog 3; Swiss-Prot: sp|Q9SYH1|RSH3C_ARATH Probable GTP diphosphokinase RSH3, chloroplastic; TrEMBL-Plants: tr|A0A0B2R105|A0A0B2R105_GLYSO Putative GTP pyrophosphokinase; Found in the gene: LotjaGi2g1v0448600
Domains
22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd05399 CDD 1 9.09