Domain Predictions — View

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IPR033671

Source: InterPro

Description

IPR033671 is a tRNA (guanosine(18)-2'-O)-methyltransferase.

<p>tRNA (guanosine(18)-2'-O)-methyltransferase (also known as tRNA [Gm18] methyltransferase, and TrmH) catalyses the 2'-O methylation of guanosine at position 18 (Gua18) in the D loop of tRNA [[cite:PUB00031978]]. In the reaction, S-adenosyl-L-methionine (AdoMet) functions as a methyl group donor and is converted to S-adenosyl-L-homocysteine (AdoHcy). The methylation of tRNA nucleotides helps to stabilize the L-shaped tRNA structure and improve their molecular recognition [[cite:PUB00079974]].</p> <p>TrmH enzymes can be classified into two types based on their substrate tRNA specificity. Type I TrmH, which includes Thermus thermophilus TrmH, can modify all tRNA species. Type II TrmH, which includes Echerichia coli TrmH and Saccharomyces cerevisiae TrmH, modifies only a subset of tRNA species [[cite:PUB00079975]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

GO term	Namespace	Name	Definition	Relationships
GO:0008168 View details of GO:0008168 AmiGO InterPro QuickGO	Molecular function	Methyltransferase activity	Catalysis of the transfer of a methyl group to an acceptor molecule.	Subterm of GO:0016741
GO:0030488 View details of GO:0030488 AmiGO InterPro QuickGO	Biological process	TRNA methylation	The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.	Subterm of GO:0001510 GO:0006400

Associated Lotus transcripts 2

Transcript	Name	Description	Predicted domains	Domain count
Lj1g3v2994560.2 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	TRNA guanosine-2'-O-methyltransferase [Medicago truncatula] gi\|357502123\|ref\|XP_003621350.1\|	Domains G3DSA:3.40.1280.10 IPR001537 IPR029026 IPR029028 IPR033671 MF_02060 NON_CYTOPLASMIC_DOMAIN PF00588 PTHR12029 PTHR12029:SF45 SIGNAL_PEPTIDE SIGNAL_PEPTIDE_C_REGION SIGNAL_PEPTIDE_H_REGION SIGNAL_PEPTIDE_N_REGION SSF75217 SignalP-TM_GRAM_POSITIVE mobidb-lite	17
LotjaGi1g1v0508500.2 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	TRNA guanosine-2'-O-methyltransferase; TAIR: AT5G15390.1 tRNA/rRNA methyltransferase (SpoU) family protein; Swiss-Prot: sp\|O67577\|TRMH_AQUAE tRNA (guanosine(18)-2'-O)-methyltransferase; TrEMBL-Plants: tr\|G7L451\|G7L451_MEDTR tRNA/rRNA methyltransferase SpoU family protein; Found in the gene: LotjaGi1g1v0508500	Domains G3DSA:3.40.1280.10 IPR001537 IPR029026 IPR029028 IPR033671 MF_02060 NON_CYTOPLASMIC_DOMAIN PF00588 PTHR43453 PTHR43453:SF1 SIGNAL_PEPTIDE SIGNAL_PEPTIDE_C_REGION SIGNAL_PEPTIDE_H_REGION SIGNAL_PEPTIDE_N_REGION SSF75217 SignalP-TM cd18092 mobidb-lite	18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain	Source	Observations	Saturation (%)
mobidb-lite	MobiDBLite	1	50.00