Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR001537 is a tRNA/rRNA methyltransferase, SpoU type.
<p>This entry represents a domain found in the spoU protein from E. coli that shows strong similarities to previously characterised 2'-O-methyltransferases [[cite:PUB00004481], [cite:PUB00004439]]. The Mrm1 protein of Saccharomyces cerevisiae has been shown to be required for ribose methylation at a universally conserved nucleotide in the peptidyl transferase centre of the mitochondrial large ribosomal RNA (21S rRNA). Cells reduced in this activity were deficient in formation of functional large subunits of the mitochondrial ribosome. The Mrm1 protein catalyzes the site-specific formation of 2'-O-methylguanosine on<i>in vitro</i>transcripts of both mitochondrial 21S rRNA and E. coli 23S rRNA providing evidence for an essential modified nucleotide in rRNA [[cite:PUB00006298]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Biological process | RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. | ||
| Molecular function | RNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | AGAMOUS-like 26 isoform 1 [Theobroma cacao] gi|508704835|gb|EOX96731.1| | 10 | ||
| – | RNA methyltransferase-like protein [Medicago truncatula] gi|357517191|ref|XP_003628884.1| | 7 | ||
| – | RNA methyltransferase-like protein [Medicago truncatula] gi|357517191|ref|XP_003628884.1| | 7 | ||
| – | RNA methyltransferase-like protein [Medicago truncatula] gi|357517191|ref|XP_003628884.1| | 13 | ||
| – | RNA methyltransferase-like protein [Medicago truncatula] gi|357517191|ref|XP_003628884.1| | 6 | ||
| – | TRNA guanosine-2'-O-methyltransferase [Medicago truncatula] gi|357502123|ref|XP_003621350.1| | 15 | ||
| – | TRNA guanosine-2'-O-methyltransferase [Medicago truncatula] gi|357502123|ref|XP_003621350.1| | 17 | ||
| – | TRNA/rRNA methyltransferase family protein isoform 1 [Theobroma cacao] gi|508776921|gb|EOY24177.1| | 8 | ||
| – | PREDICTED: 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB-like [Cicer arietinum] gi|502151214|ref|XP_004508331.1| | 8 | ||
| – | TRNA/rRNA methyltransferase family protein [Theobroma cacao] gi|508783395|gb|EOY30651.1| | 16 | ||
| – | TRNA guanosine-2'-O-methyltransferase; TAIR: AT5G15390.1 tRNA/rRNA methyltransferase (SpoU) family protein; Swiss-Prot: sp|O67577|TRMH_AQUAE tRNA (guanosine(18)-2'-O)-methyltransferase; TrEMBL-Plants: tr|G7L451|G7L451_MEDTR tRNA/rRNA methyltransferase SpoU family protein; Found in the gene: LotjaGi1g1v0508500 | 9 | ||
| – | TRNA guanosine-2'-O-methyltransferase; TAIR: AT5G15390.1 tRNA/rRNA methyltransferase (SpoU) family protein; Swiss-Prot: sp|O67577|TRMH_AQUAE tRNA (guanosine(18)-2'-O)-methyltransferase; TrEMBL-Plants: tr|G7L451|G7L451_MEDTR tRNA/rRNA methyltransferase SpoU family protein; Found in the gene: LotjaGi1g1v0508500 | 18 | ||
| – | RRNA methyltransferase; TAIR: AT4G38020.1 tRNA/rRNA methyltransferase (SpoU) family protein; Swiss-Prot: sp|P94538|YSGA_BACSU Uncharacterized tRNA/rRNA methyltransferase YsgA; TrEMBL-Plants: tr|G7LIJ4|G7LIJ4_MEDTR tRNA/rRNA methyltransferase SpoU family protein; Found in the gene: LotjaGi4g1v0173100 | 13 | ||
| – | TRNA/rRNA methyltransferase family protein; TAIR: AT4G17610.2 tRNA/rRNA methyltransferase (SpoU) family protein; Swiss-Prot: sp|Q13395|TARB1_HUMAN Probable methyltransferase TARBP1; TrEMBL-Plants: tr|A0A0R0FD66|A0A0R0FD66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0195000 | 14 | ||
| – | TRNA guanosine-2'-O-methyltransferase; TAIR: AT4G15520.1 tRNA/rRNA methyltransferase (SpoU) family protein; Swiss-Prot: sp|Q6FF50|RLMB_ACIAD 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB; TrEMBL-Plants: tr|K7MJI7|K7MJI7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0348400 | 9 | ||
| – | RRNA methyltransferase; TAIR: AT2G19870.1 tRNA/rRNA methyltransferase (SpoU) family protein; Swiss-Prot: sp|O94631|MRM1_SCHPO rRNA methyltransferase 1, mitochondrial; TrEMBL-Plants: tr|I1KPW8|I1KPW8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0445300 | 18 | ||
| – | TRNA (cytidine(34)-2'-O)-methyltransferase; TAIR: AT5G26880.1 tRNA (cytidine(34)-2'-O)-methyltransferase; Swiss-Prot: sp|P74516|TRML_SYNY3 Putative tRNA (cytidine(34)-2'-O)-methyltransferase; TrEMBL-Plants: tr|I3S4V5|I3S4V5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0261900 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18094 | CDD | 1 | 5.88 |