Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR007695 is a DNA mismatch repair protein MutS-like, N-terminal.
<p>Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The post-replicative Mismatch Repair System (MMRS) of Escherichia coli involves MutS (Mutator S), MutL and MutH proteins, and acts to correct point mutations or small insertion/deletion loops produced during DNA replication [[cite:PUB00042612]]. MutS and MutL are involved in preventing recombination between partially homologous DNA sequences. The assembly of MMRS is initiated by MutS, which recognises and binds to mispaired nucleotides and allows further action of MutL and MutH to eliminate a portion of newly synthesized DNA strand containing the mispaired base [[cite:PUB00042613]]. MutS can also collaborate with methyltransferases in the repair of O(6)-methylguanine damage, which would otherwise pair with thymine during replication to create an O(6)mG:T mismatch [[cite:PUB00042614]]. MutS exists as a dimer, where the two monomers have different conformations and form a heterodimer at the structural level [[cite:PUB00042218]]. Only one monomer recognises the mismatch specifically and has ADP bound. Non-specific major groove DNA-binding domains from both monomers embrace the DNA in a clamp-like structure. Mismatch binding induces ATP uptake and a conformational change in the MutS protein, resulting in a clamp that translocates on DNA.</p> <p>This entry represents the N-terminal domain of proteins in the MutS family of DNA mismatch repair proteins, as well as closely related proteins. The N-terminal domain of MutS is responsible for mismatch recognition and forms a 6-stranded mixed β-sheet surrounded by three α-helices, which is similar to the structure of tRNA endonuclease. Yeast MSH3 [[cite:PUB00003761]], bacterial proteins involved in DNA mismatch repair, and the predicted protein product of the Rep-3 gene of mouse share extensive sequence similarity. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | ||
| Molecular function | Mismatched DNA binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA mismatch repair protein MSH1, mitochondrial-like [Cicer arietinum] gi|502122529|ref|XP_004497789.1| | 15 | ||
| – | PREDICTED: DNA mismatch repair protein MSH7-like [Cicer arietinum] gi|502163835|ref|XP_004512965.1| | 24 | ||
| – | PREDICTED: DNA mismatch repair protein Msh6-1-like [Glycine max] gi|356572787|ref|XP_003554547.1| | 13 | ||
| – | PREDICTED: DNA mismatch repair protein MSH7-like [Cicer arietinum] gi|502163835|ref|XP_004512965.1| | 9 | ||
| – | PREDICTED: DNA mismatch repair protein Msh2-like [Glycine max] gi|356563103|ref|XP_003549805.1| | 25 | ||
| – | PREDICTED: DNA mismatch repair protein MSH3-like isoform X1 [Cicer arietinum] gi|502119328|ref|XP_004496581.1| | 25 | ||
| – | DNA mismatch repair protein MutS; TAIR: AT4G02070.1 MUTS homolog 6; Swiss-Prot: sp|O04716|MSH6_ARATH DNA mismatch repair protein MSH6; TrEMBL-Plants: tr|A0A151RYF4|A0A151RYF4_CAJCA DNA mismatch repair protein Msh6-1; Found in the gene: LotjaGi1g1v0760200 | 35 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G24495.1 MUTS homolog 7; Swiss-Prot: sp|Q9SMV7|MSH7_ARATH DNA mismatch repair protein MSH7; TrEMBL-Plants: tr|G7KNH7|G7KNH7_MEDTR DNA mismatch repair protein msh6; Found in the gene: LotjaGi2g1v0214200 | 29 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800 | 30 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT4G25540.1 homolog of DNA mismatch repair protein MSH3; Swiss-Prot: sp|O65607|MSH3_ARATH DNA mismatch repair protein MSH3; TrEMBL-Plants: tr|A0A072VPI7|A0A072VPI7_MEDTR DNA mismatch repair MSH3-like protein; Found in the gene: LotjaGi5g1v0301900 | 28 | ||
| – | DNA mismatch repair protein mutS; TAIR: AT3G24320.1 MUTL protein homolog 1; Swiss-Prot: sp|Q84LK0|MSH1_ARATH DNA mismatch repair protein MSH1, mitochondrial; TrEMBL-Plants: tr|G7I6Q0|G7I6Q0_MEDTR DNA mismatch repair protein; Found in the gene: LotjaGi6g1v0010300 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03243 | CDD | 1 | 9.09 |