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IPR037431 is a RNA exonuclease 4, DEDDh 3'-5' exonuclease domain.
<p>This entry represent the DEDDh 3'-5' exonuclease domain found in RNA exonuclease 4 (REX4 or Rex4p) [[cite:PUB00084621]]. It is a DEDDh-type DnaQ-like 3'-5' exonuclease containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis [[cite:PUB00032146]]. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherchia coli RNase T [[cite:PUB00041750]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | RRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. | ||
| Molecular function | 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RNA exonuclease 4; TAIR: AT3G27970.1 Exonuclease family protein; Swiss-Prot: sp|Q9GZR2|REXO4_HUMAN RNA exonuclease 4; TrEMBL-Plants: tr|A0A0R0EJ11|A0A0R0EJ11_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0607200 | 15 | ||
| – | RNA exonuclease 4; TAIR: AT3G27970.1 Exonuclease family protein; Swiss-Prot: sp|Q9GZR2|REXO4_HUMAN RNA exonuclease 4; TrEMBL-Plants: tr|A0A151QYX1|A0A151QYX1_CAJCA RNA exonuclease 4; Found in the gene: LotjaGi1g1v0607200 | 11 | ||
| – | RNA exonuclease 4; TAIR: AT3G27970.1 Exonuclease family protein; Swiss-Prot: sp|Q9GZR2|REXO4_HUMAN RNA exonuclease 4; TrEMBL-Plants: tr|A0A0S3RW52|A0A0S3RW52_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0607200 | 14 | ||
| – | RNA exonuclease-like protein; TAIR: AT3G27970.1 Exonuclease family protein; Swiss-Prot: sp|Q9GZR2|REXO4_HUMAN RNA exonuclease 4; TrEMBL-Plants: tr|A0A0B2RL39|A0A0B2RL39_GLYSO RNA exonuclease 4; Found in the gene: LotjaGi3g1v0024300 | 14 | ||
| – | RNA exonuclease-like protein; TAIR: AT3G27970.1 Exonuclease family protein; Swiss-Prot: sp|Q9GZR2|REXO4_HUMAN RNA exonuclease 4; TrEMBL-Plants: tr|A0A0B2RL39|A0A0B2RL39_GLYSO RNA exonuclease 4; Found in the gene: LotjaGi3g1v0024300 | 14 | ||
| – | RNA exonuclease 4; TAIR: AT3G15080.1 Polynucleotidyl transferase, ribonuclease H-like superfamily protein; Swiss-Prot: sp|Q91560|REXO4_XENLA RNA exonuclease 4; TrEMBL-Plants: tr|A0A151R8G2|A0A151R8G2_CAJCA RNA exonuclease 4; Found in the gene: LotjaGi3g1v0155200 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |