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IPR037550 is a Sec23, C-terminal.
<p>Vesicular carriers mediate a continuous flux of proteins and lipids between endoplasmic reticulum (ER) and the Golgi. Anterograde and retrograde transport is mediated by distinct sets of cytosolic coat proteins, the COPI and COPII coats, respectively, which act on the membrane to capture cargo proteins into nascent vesicles [[cite:PUB00086815]].</p> <p>Sec23 is a component of the coat protein complex II (COPII). Polymerization of the coat requires the recruitment of the Sec13/Sec31 complex (coat outer shell) by the Sec23/Sec24 complex. The Sec23/Sec24 coat complex then sorts the fusion machinery (SNAREs) into vesicles as they bud from the ER. Sec23 has been shown to interact in a sequential manner with other proteins (Sar1, TRAPPI and Hrr25) to control the direction of anterograde membrane flow [[cite:PUB00086816]].</p> <p>This entry represents the C-terminal domain of Sec23. This domain is distantly related to gelsolin-like repeats and the actin depolymerizing domains found in cofilin and similar proteins. The function of the Sec23 C-terminal domain is unclear.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | COPII vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. | ||
| Biological process | COPII-coated vesicle budding | The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein transport protein SEC23; TAIR: AT2G21630.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|G7LEA6|G7LEA6_MEDTR Protein transporter Sec23-like protein; Found in the gene: LotjaGi3g1v0268900 | 30 | ||
| – | Protein transport protein SEC23; TAIR: AT2G21630.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|G7LEA6|G7LEA6_MEDTR Protein transporter Sec23-like protein; Found in the gene: LotjaGi3g1v0268900 | 30 | ||
| – | Protein transport protein SEC23; TAIR: AT1G05520.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|A0A1J7GI99|A0A1J7GI99_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0368900 | 30 | ||
| – | Protein transport protein SEC23; TAIR: AT5G43670.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|G8A123|G8A123_MEDTR Protein transporter Sec23-like protein; Found in the gene: LotjaGi6g1v0038800 | 30 | ||
| – | Protein transport protein SEC23; TAIR: AT1G05520.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|G7JBC0|G7JBC0_MEDTR Protein transporter Sec23-like protein; Found in the gene: LotjaGi6g1v0103600 | 31 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11287 | CDD | 1 | 20.00 |