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IPR040097 is a Fatty acyl-AMP ligase /fatty acyl-CoA ligase.
<p>Fatty acyl-AMP ligase (FAAL) belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin [[cite:PUB00058674], [cite:PUB00100722]].</p> <p>FAAL sequences are also found at the N terminus of non-ribosomal peptide synthetases, large modular enzymes that catalyse synthesis of important peptide products [[cite:PUB00094570]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | AMP-dependent synthetase and ligase family protein; TAIR: AT1G20480.1 AMP-dependent synthetase and ligase family protein; Swiss-Prot: sp|B2HIM0|FAA28_MYCMM Long-chain-fatty-acid--AMP ligase FadD28; TrEMBL-Plants: tr|A0A0B2RJD7|A0A0B2RJD7_GLYSO Long-chain-fatty-acid--AMP ligase FadD28; Found in the gene: LotjaGi3g1v0292200 | 48 | ||
| – | Acyl-CoA ligase-like; TAIR: AT1G20480.1 AMP-dependent synthetase and ligase family protein; Swiss-Prot: sp|B2HIM0|FAA28_MYCMM Long-chain-fatty-acid--AMP ligase FadD28; TrEMBL-Plants: tr|A0A0B2QZ83|A0A0B2QZ83_GLYSO Long-chain-fatty-acid--AMP ligase FadD28; Found in the gene: LotjaGi3g1v0496500 | 29 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05931 | CDD | 1 | 50.00 |