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IPR020806 is a Polyketide synthase, phosphopantetheine-binding domain.
<p>This entry represents the phosphopantetheine-binding domain from polyketide synthases. Polyketide synthases are large multidomain proteins involved in the synthesis of secondary metabolites [[cite:PUB00057835]].</p> <p>Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups [[cite:PUB00002372]].</p> <p>The amino-terminal region of the ACP proteins is well defined and consists of four α helices arranged in a right-handed bundle held together by interhelical hydrophobic interactions. The Asp-Ser-Leu (DSL) motif is conserved in all of the ACP sequences, and the 4'-PP prosthetic group is covalently linked via a phosphodiester bond to the serine residue. The DSL sequence is present at the amino terminus of helix II, a domain of the protein referred to as the recognition helix and which is responsible for the interaction of ACPs with the enzymes of type II fatty acid synthesis [[cite:PUB00007945]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phosphopantetheine binding | Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Bifunctional protein aas [Medicago truncatula] gi|357454395|ref|XP_003597478.1| | 32 | ||
| – | 24 | |||
| – | 30 | |||
| – | 26 | |||
| – | PREDICTED: acyl carrier protein 1, chloroplastic-like [Glycine max] gi|356535129|ref|XP_003536101.1| | 15 | ||
| – | PREDICTED: acyl carrier protein 1, chloroplastic-like [Cicer arietinum] gi|502078834|ref|XP_004486070.1| | 16 | ||
| – | AMP-dependent synthetase and ligase family protein; TAIR: AT1G20480.1 AMP-dependent synthetase and ligase family protein; Swiss-Prot: sp|B2HIM0|FAA28_MYCMM Long-chain-fatty-acid--AMP ligase FadD28; TrEMBL-Plants: tr|A0A0B2RJD7|A0A0B2RJD7_GLYSO Long-chain-fatty-acid--AMP ligase FadD28; Found in the gene: LotjaGi3g1v0292200 | 48 | ||
| – | Acyl carrier protein; TAIR: AT4G25050.1 acyl carrier protein 4; Swiss-Prot: sp|P93092|ACP1_CASGL Acyl carrier protein 1, chloroplastic; TrEMBL-Plants: tr|I3T1G9|I3T1G9_LOTJA Acyl carrier protein; Found in the gene: LotjaGi4g1v0420700 | 15 | ||
| – | Acyl carrier protein; TAIR: AT3G05020.1 acyl carrier protein 1; Swiss-Prot: sp|P93092|ACP1_CASGL Acyl carrier protein 1, chloroplastic; TrEMBL-Plants: tr|I3T3K1|I3T3K1_LOTJA Acyl carrier protein; Found in the gene: LotjaGi5g1v0217100 | 15 | ||
| – | Acyl carrier protein; TAIR: AT1G54630.1 acyl carrier protein 3; Swiss-Prot: sp|P93092|ACP1_CASGL Acyl carrier protein 1, chloroplastic; TrEMBL-Plants: tr|I3SIS1|I3SIS1_LOTJA Acyl carrier protein; Found in the gene: LotjaGi6g1v0305200 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00517 | TIGRFAM | 1 | 10.00 |