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IPR042277 is a Vacuolar protein sorting-associated protein IST1-like.
<p>The endosomal sorting complex required for transport (ESCRT) machinery functions in several important eukaryotic cellular processes such as MVB (multivesicular body) formation. The AAA-ATPase Vps4 catalyzes disassembly of the ESCRT-III complex and may regulate membrane deformation and vesicle scission as well. Ist1 acts as a negative regulator of the MVB pathway by binding to the N-terminal MIT (microtubule interacting and transport) domain of Vps4 through its C-terminal region, with its 15 amino acids bearing strong homology to a conserved sequence motif called MIM1 (MIT interacting motif 1 [[cite:PUB00052965]]). This MIT domain is found in various proteins and enzymes including ubiquitin hydrolases proteases, ATPases (Spastin and VPS4 proteins) and ATPase activators (Vta1p/LIP5) [[cite:PUB00052035]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1N5C7|I1N5C7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0251500 | 11 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1N5C7|I1N5C7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0551000 | 12 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G34220.2 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1MNZ8|I1MNZ8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0095800 | 8 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT4G32350.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A072UBV7|A0A072UBV7_MEDTR Regulator of Vps4 activity in the MVB pathway protein; Found in the gene: LotjaGi2g1v0215300 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT2G19710.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|K7K129|K7K129_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0230600 | 9 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I3T1U7|I3T1U7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0278600 | 8 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A151QR33|A0A151QR33_CAJCA IST1-like protein; Found in the gene: LotjaGi2g1v0278600 | 8 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A151QR33|A0A151QR33_CAJCA IST1-like protein; Found in the gene: LotjaGi2g1v0278600 | 8 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G79910.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A0L9UPT2|A0A0L9UPT2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0016900 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G79910.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1KG75|I1KG75_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0363400 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT2G14830.1 Ist1p; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1LUF3|I1LUF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0442900 | 13 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT4G35730.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A0B2RT62|A0A0B2RT62_GLYSO IST1-like protein; Found in the gene: LotjaGi4g1v0134300 | 13 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT4G32350.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|G7L8X5|G7L8X5_MEDTR Regulator of Vps4 activity in the MVB pathway protein; Found in the gene: LotjaGi4g1v0449700 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G25420.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q3ZBV1|IST1_BOVIN IST1 homolog; TrEMBL-Plants: tr|I3T1I6|I3T1I6_MEDTR Uncharacterized protein; Found in the gene: LotjaGi5g1v0339600 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G25420.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q3ZBV1|IST1_BOVIN IST1 homolog; TrEMBL-Plants: tr|C6TKA2|C6TKA2_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0339600 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1N5C7|I1N5C7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0030600 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR12161:SF43 | PANTHER | 1 | 6.25 |