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IPR005061 is a Vacuolar protein sorting-associated protein Ist1.
<p>Budding yeast Ist1 is involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles [[cite:PUB00077601]]. This entry also includes Ist1 homologues from animals and plants. Human Ist1 functions in the ESCRT (endosomal sorting complexes required for transport) pathway and is required for efficient abscission during HeLa cell cytokinesis [[cite:PUB00077602]]. Human Ist1 binds the transport (MIT) domain of VPS4, LIP5, and Spartin via its C-terminal MIT-interacting motif (MIM) [[cite:PUB00077607]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: IST1-like protein-like [Solanum lycopersicum] gi|460373115|ref|XP_004232368.1| | 4 | ||
| – | PREDICTED: IST1-like protein-like [Solanum lycopersicum] gi|460373115|ref|XP_004232368.1| | 9 | ||
| – | IST1-like protein [Medicago truncatula] gi|357521021|ref|XP_003630799.1| | 5 | ||
| – | PREDICTED: dentin sialophosphoprotein-like [Cicer arietinum] gi|502092161|ref|XP_004489726.1| | 5 | ||
| – | PREDICTED: dentin sialophosphoprotein-like [Cicer arietinum] gi|502092161|ref|XP_004489726.1| | 4 | ||
| – | PREDICTED: IST1-like protein-like [Cicer arietinum] gi|502153639|ref|XP_004509413.1| | 10 | ||
| – | PREDICTED: IST1-like protein-like [Cicer arietinum] gi|502153639|ref|XP_004509413.1| | 4 | ||
| – | PREDICTED: IST1-like protein-like [Solanum lycopersicum] gi|460373115|ref|XP_004232368.1| | 8 | ||
| – | PREDICTED: IST1-like protein-like [Solanum lycopersicum] gi|460373115|ref|XP_004232368.1| | 10 | ||
| – | IST1-like protein [Medicago truncatula] gi|357521021|ref|XP_003630799.1| | 5 | ||
| – | IST1-like protein [Medicago truncatula] gi|357521021|ref|XP_003630799.1| | 5 | ||
| – | PREDICTED: dentin sialophosphoprotein-like [Cicer arietinum] gi|502164221|ref|XP_004513087.1| | 6 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein [Arabidopsis thaliana] gi|15222251|ref|NP_172792.1| | 6 | ||
| – | IST1-like protein [Medicago truncatula] gi|357454973|ref|XP_003597767.1| | 5 | ||
| – | IST1-like protein [Medicago truncatula] gi|357470901|ref|XP_003605735.1| | 11 | ||
| – | IST1-like protein [Medicago truncatula] gi|357521021|ref|XP_003630799.1| | 5 | ||
| – | PREDICTED: IST1 homolog isoform X2 [Cicer arietinum] gi|502120799|ref|XP_004497086.1| | 5 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1N5C7|I1N5C7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0251500 | 11 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1N5C7|I1N5C7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0551000 | 12 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G34220.2 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1MNZ8|I1MNZ8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0095800 | 8 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT4G32350.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A072UBV7|A0A072UBV7_MEDTR Regulator of Vps4 activity in the MVB pathway protein; Found in the gene: LotjaGi2g1v0215300 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT2G19710.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|K7K129|K7K129_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0230600 | 9 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I3T1U7|I3T1U7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0278600 | 8 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A151QR33|A0A151QR33_CAJCA IST1-like protein; Found in the gene: LotjaGi2g1v0278600 | 8 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A151QR33|A0A151QR33_CAJCA IST1-like protein; Found in the gene: LotjaGi2g1v0278600 | 8 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G79910.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A0L9UPT2|A0A0L9UPT2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0016900 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G79910.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1KG75|I1KG75_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0363400 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT2G14830.1 Ist1p; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1LUF3|I1LUF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0442900 | 13 | ||
| – | Mediator of RNA polymerase II transcription subunit-like protein, putative (DUF1216); TAIR: AT3G28980.1 mediator of RNA polymerase II transcription subunit-like protein, putative (DUF1216); Swiss-Prot: sp|Q18DN4|HMU_HALWD Halomucin; TrEMBL-Plants: tr|A0A178VB59|A0A178VB59_ARATH Uncharacterized protein; Found in the gene: LotjaGi4g1v0037600_LC | 14 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT4G35730.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|A0A0B2RT62|A0A0B2RT62_GLYSO IST1-like protein; Found in the gene: LotjaGi4g1v0134300 | 13 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT4G32350.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|G7L8X5|G7L8X5_MEDTR Regulator of Vps4 activity in the MVB pathway protein; Found in the gene: LotjaGi4g1v0449700 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G25420.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q3ZBV1|IST1_BOVIN IST1 homolog; TrEMBL-Plants: tr|I3T1I6|I3T1I6_MEDTR Uncharacterized protein; Found in the gene: LotjaGi5g1v0339600 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G25420.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q3ZBV1|IST1_BOVIN IST1 homolog; TrEMBL-Plants: tr|C6TKA2|C6TKA2_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0339600 | 7 | ||
| – | Regulator of Vps4 activity in the MVB pathway protein; TAIR: AT1G13340.1 Regulator of Vps4 activity in the MVB pathway protein; Swiss-Prot: sp|Q54I39|IST1L_DICDI IST1-like protein; TrEMBL-Plants: tr|I1N5C7|I1N5C7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0030600 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR12161:SF43 | PANTHER | 1 | 2.94 |