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PF00186

Source: Pfam

Description

Dihydrofolate reductase

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004146
Molecular function Dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
Subterm of
GO:0046654
Biological process Tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 14

Transcript Name Description Predicted domains Domain count
Lj1g3v3381400.1
– PREDICTED: bifunctional dihydrofolate reductase-thymidylate synthase-like [Cicer arietinum] gi|502130863|ref|XP_004500795.1|
Domains
17
Lj1g3v3381400.2
– PREDICTED: bifunctional dihydrofolate reductase-thymidylate synthase-like [Cicer arietinum] gi|502130863|ref|XP_004500795.1|
Domains
24
Lj3g3v3363560.1
– CM0216.390.nc [Lotus japonicus] gi|164564740|dbj|BAF98221.1|
Domains
20
LotjaGi1g1v0565200.1
– Thymidylate synthase; TAIR: AT2G16370.1 thymidylate synthase 1; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|I1K754|I1K754_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi1g1v0565200
Domains
25
LotjaGi1g1v0565200.2
– Thymidylate synthase; TAIR: AT2G16370.1 thymidylate synthase 1; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|I1K753|I1K753_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi1g1v0565200
Domains
25
LotjaGi1g1v0565200.3
– Thymidylate synthase; TAIR: AT2G16370.1 thymidylate synthase 1; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|I1K753|I1K753_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi1g1v0565200
Domains
25
LotjaGi1g1v0565200.4
– Thymidylate synthase; TAIR: AT4G34570.4 thymidylate synthase 2; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|I1K753|I1K753_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi1g1v0565200
Domains
24
LotjaGi1g1v0565200.5
– Bifunctional dihydrofolate reductase-thymidylate synthase; TAIR: AT2G16370.1 thymidylate synthase 1; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|I1K753|I1K753_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi1g1v0565200
Domains
17
LotjaGi1g1v0565200.6
– Dihydrofolate reductase / thymidylate synthase; TAIR: AT4G34570.1 thymidylate synthase 2; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|I1K753|I1K753_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi1g1v0565200
Domains
24
LotjaGi1g1v0565200.7
– Thymidylate synthase; TAIR: AT2G16370.1 thymidylate synthase 1; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|I1K753|I1K753_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi1g1v0565200
Domains
25
LotjaGi3g1v0510900.1
– Thymidylate synthase; TAIR: AT4G34570.4 thymidylate synthase 2; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|B0BLI5|B0BLI5_LOTJA Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi3g1v0510900
Domains
23
LotjaGi3g1v0510900.2
– Bifunctional dihydrofolate reductase-thymidylate synthase; TAIR: AT2G16370.1 thymidylate synthase 1; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|B0BLI5|B0BLI5_LOTJA Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi3g1v0510900
Domains
15
LotjaGi3g1v0510900.3
– Thymidylate synthase; TAIR: AT4G34570.4 thymidylate synthase 2; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|B0BLI5|B0BLI5_LOTJA Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi3g1v0510900
Domains
22
LotjaGi3g1v0510900.4
– Thymidylate synthase; TAIR: AT4G34570.4 thymidylate synthase 2; Swiss-Prot: sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase; TrEMBL-Plants: tr|B0BLI5|B0BLI5_LOTJA Bifunctional dihydrofolate reductase-thymidylate synthase; Found in the gene: LotjaGi3g1v0510900
Domains
23

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00351 CDD 1 7.14