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Field | Value |
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Namespace | Cellular component |
Short description | Nascent polypeptide-associated complex |
Full defintion | A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. |
Subterm of |
The relationship of GO:0005854 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0005854, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent-polypeptide-associated complex. Proc Natl Acad Sci U S A. 1995 Oct 10; 92 (21): 9435–9.PMID: 7568149 Signal peptides direct the cotranslational targeting of nascent polypeptides to the endoplasmic reticulum (ER). It is currently believed that the signal recognition particle (SRP) mediates this targeting by first binding to signal peptides and then by directing the ribosome/nascent chain/SRP complex to the SRP receptor at the ER. We show that ribosomes can mediate targeting by directly binding to translocation sites. When purified away from cytosolic factors, including SRP and nascent-polypeptide-associated complex (NAC), in vitro assembled translation intermediates representing ribosome/nascent-chain complexes efficiently bound to microsomal membranes, and their nascent polypeptides could subsequently be efficiently translocated. Because removal of cytosolic factors from the ribosome/nascent-chain complexes also resulted in mistargeting of signalless nascent polypeptides, we previously investigated whether readdition of cytosolic factors, such as NAC and SRP, could restore fidelity to targeting. Without SRP, NAC prevented all nascent-chain-containing ribosomes from binding to the ER membrane. Furthermore, SRP prevented NAC from blocking ribosome-membrane association only when the nascent polypeptide contained a signal. Thus, NAC is a global ribosome-binding prevention factor regulated in activity by signal-peptide-directed SRP binding. A model presents ribosomes as the targeting vectors for delivering nascent polypeptides to translocation sites. In conjunction with signal peptides, SRP and NAC contribute to this specificity of ribosomal function by regulating exposure of a ribosomal membrane attachment site that binds to receptors in the ER membrane. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
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– | Nascent polypeptide-associated complex subunit alpha [Medicago truncatula] gi|357464241|ref|XP_003602402.1| | 1 | ||
– | PREDICTED: nascent polypeptide-associated complex subunit alpha-like protein 2-like [Glycine max] gi|356516170|ref|XP_003526769.1| | 1 | ||
– | PREDICTED: nascent polypeptide-associated complex subunit alpha-like protein-like [Glycine max] gi|356571874|ref|XP_003554096.1| | 1 | ||
– | PREDICTED: nascent polypeptide-associated complex subunit alpha-like protein 1-like [Cicer arietinum] gi|502107593|ref|XP_004493313.1| | 1 | ||
– | Nascent polypeptide associated complex alpha subunit, putative; TAIR: AT3G49470.1 nascent polypeptide-associated complex subunit alpha-like protein 2; Swiss-Prot: sp|Q94JX9|NACA2_ARATH Nascent polypeptide-associated complex subunit alpha-like protein 2; TrEMBL-Plants: tr|I3S057|I3S057_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0042200 | 1 | ||
– | Nascent polypeptide associated complex alpha subunit, putative; TAIR: AT3G49470.1 nascent polypeptide-associated complex subunit alpha-like protein 2; Swiss-Prot: sp|Q94JX9|NACA2_ARATH Nascent polypeptide-associated complex subunit alpha-like protein 2; TrEMBL-Plants: tr|I3SFN2|I3SFN2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0300500 | 1 | ||
– | Nascent polypeptide-associated complex subunit alpha-like protein; TAIR: AT3G12390.1 Nascent polypeptide-associated complex (NAC), alpha subunit family protein; Swiss-Prot: sp|Q9M612|NACA_PINTA Nascent polypeptide-associated complex subunit alpha-like protein; TrEMBL-Plants: tr|I3T8X0|I3T8X0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0656900 | 1 | ||
– | Nascent polypeptide-associated complex subunit alpha-like protein; TAIR: AT3G12390.1 Nascent polypeptide-associated complex (NAC), alpha subunit family protein; Swiss-Prot: sp|Q9M612|NACA_PINTA Nascent polypeptide-associated complex subunit alpha-like protein; TrEMBL-Plants: tr|I3T8X0|I3T8X0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0656900 | 1 | ||
– | Nascent polypeptide-associated complex subunit alpha-like protein; TAIR: AT3G12390.1 Nascent polypeptide-associated complex (NAC), alpha subunit family protein; Swiss-Prot: sp|Q9M612|NACA_PINTA Nascent polypeptide-associated complex subunit alpha-like protein; TrEMBL-Plants: tr|I3T8X0|I3T8X0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0656900 | 1 | ||
– | Nascent polypeptide-associated complex subunit alpha-like protein; TAIR: AT3G12390.1 Nascent polypeptide-associated complex (NAC), alpha subunit family protein; Swiss-Prot: sp|Q9M612|NACA_PINTA Nascent polypeptide-associated complex subunit alpha-like protein; TrEMBL-Plants: tr|I3S1S2|I3S1S2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0656900 | 1 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | Nascent polypeptide-associated complex | 1 | 10.00 |