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GO:0008420

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description RNA polymerase II CTD heptapeptide repeat phosphatase activity
Full defintion Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate.
Subterm of

Relationships

The relationship of GO:0008420 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Updating the RNA polymerase CTD code: adding gene-specific layers.Egloff S, Dienstbier M, Murphy S
Trends Genet. 2012 Jul; 28 (7): 333–41.PMID: 22622228

The carboxyl-terminal domain (CTD) of RNA polymerase (pol) II comprises multiple tandem repeats with the consensus sequence Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7) that can be extensively and reversibly modified in vivo. CTD modifications orchestrate the interplay between transcription and processing of mRNA. Although phosphorylation of Ser2 (Ser2P) and Ser5 (Ser5P) residues has been described as being essential for the expression of most pol II-transcribed genes, recent findings highlight gene-specific effects of newly discovered CTD modifications. Here, we incorporate these latest findings in an updated review of the currently known elements that contribute to the CTD code and how it is recognized by proteins involved in transcription and RNA maturation. As modification of the CTD has a major impact on gene expression, a better understanding of the CTD code is integral to the understanding of how gene expression is regulated.

Associated Lotus transcripts 10

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi1g1v0439500.1
– RNA polymerase II C-terminal domain phosphatase-like 2; TAIR: AT5G01270.1 carboxyl-terminal domain (ctd) phosphatase-like 2; Swiss-Prot: sp|Q5YDB5|CPL2_ARATH RNA polymerase II C-terminal domain phosphatase-like 2; TrEMBL-Plants: tr|K7L1T3|K7L1T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0439500
GO terms
2
LotjaGi1g1v0529200.1
– RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT2G33540.1 C-terminal domain phosphatase-like 3; Swiss-Prot: sp|Q8LL04|CPL3_ARATH RNA polymerase II C-terminal domain phosphatase-like 3; TrEMBL-Plants: tr|I1KWR8|I1KWR8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529200
GO terms
2
LotjaGi1g1v0661000.1
– RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A072UR90|A0A072UR90_MEDTR Carboxy-terminal domain phosphatase-like protein; Found in the gene: LotjaGi1g1v0661000
GO terms
2
LotjaGi3g1v0282700.1
– RNA polymerase II subunit B1 CTD phosphatase RPAP2, putative; TAIR: AT5G26760.2 RNA polymerase II subunit B1 CTD phosphatase RPAP2-like protein; Swiss-Prot: sp|F4K1B1|RPAP2_ARATH Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog; TrEMBL-Plants: tr|I1JGF0|I1JGF0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0282700
GO terms
3
LotjaGi3g1v0282700.2
– RNA polymerase II subunit B1 CTD phosphatase RPAP2, putative; TAIR: AT5G26760.2 RNA polymerase II subunit B1 CTD phosphatase RPAP2-like protein; Swiss-Prot: sp|F4K1B1|RPAP2_ARATH Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog; TrEMBL-Plants: tr|I1JGF0|I1JGF0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0282700
GO terms
3
LotjaGi4g1v0054200.1
– RNA polymerase II C-terminal domain phosphatase-like 1; TAIR: AT4G21670.1 C-terminal domain phosphatase-like 1; Swiss-Prot: sp|Q5YDB6|CPL1_ARATH RNA polymerase II C-terminal domain phosphatase-like 1; TrEMBL-Plants: tr|A0A0S3QZI5|A0A0S3QZI5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0054200
GO terms
2
LotjaGi4g1v0286500.1
– RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.3 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A151SFP9|A0A151SFP9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0286500
GO terms
2
LotjaGi4g1v0287100.1
– RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|V7BX02|V7BX02_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0287100
GO terms
2
LotjaGi4g1v0287100.2
– RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A0L9TRV4|A0A0L9TRV4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0287100
GO terms
2
LotjaGi5g1v0107900.1
– RNA polymerase II subunit B1 CTD phosphatase RPAP2, putative; TAIR: AT5G26760.2 RNA polymerase II subunit B1 CTD phosphatase RPAP2-like protein; Swiss-Prot: sp|F4K1B1|RPAP2_ARATH Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog; TrEMBL-Plants: tr|I1JGF0|I1JGF0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0107900
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0070940
Biological process Dephosphorylation of RNA polymerase II C-terminal domain 1 10.00