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Field | Value |
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Namespace | Biological process |
Short description | Dephosphorylation of RNA polymerase II C-terminal domain |
Full defintion | The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form. |
Subterm of |
The relationship of GO:0070940 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0070940, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | mah |
PMID | Phosphorylation and functions of the RNA polymerase II CTD. Genes Dev. 2006 Nov 1; 20 (21): 2922–36.PMID: 17079683 The C-terminal repeat domain (CTD), an unusual extension appended to the C terminus of the largest subunit of RNA polymerase II, serves as a flexible binding scaffold for numerous nuclear factors; which factors bind is determined by the phosphorylation patterns on the CTD repeats. Changes in phosphorylation patterns, as polymerase transcribes a gene, are thought to orchestrate the association of different sets of factors with the transcriptase and strongly influence functional organization of the nucleus. In this review we appraise what is known, and what is not known, about patterns of phosphorylation on the CTD of RNA polymerases II at the beginning, the middle, and the end of genes; the proposal that doubly phosphorylated repeats are present on elongating polymerase is explored. We discuss briefly proteins known to associate with the phosphorylated CTD at the beginning and ends of genes; we explore in more detail proteins that are recruited to the body of genes, the diversity of their functions, and the potential consequences of tethering these functions to elongating RNA polymerase II. We also discuss accumulating structural information on phosphoCTD-binding proteins and how it illustrates the variety of binding domains and interaction modes, emphasizing the structural flexibility of the CTD. We end with a number of open questions that highlight the extent of what remains to be learned about the phosphorylation and functions of the CTD. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | RNA polymerase II C-terminal domain phosphatase-like 2; TAIR: AT5G01270.1 carboxyl-terminal domain (ctd) phosphatase-like 2; Swiss-Prot: sp|Q5YDB5|CPL2_ARATH RNA polymerase II C-terminal domain phosphatase-like 2; TrEMBL-Plants: tr|K7L1T3|K7L1T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0439500 | 2 | ||
– | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT2G33540.1 C-terminal domain phosphatase-like 3; Swiss-Prot: sp|Q8LL04|CPL3_ARATH RNA polymerase II C-terminal domain phosphatase-like 3; TrEMBL-Plants: tr|I1KWR8|I1KWR8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529200 | 2 | ||
– | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A072UR90|A0A072UR90_MEDTR Carboxy-terminal domain phosphatase-like protein; Found in the gene: LotjaGi1g1v0661000 | 2 | ||
– | RNA polymerase II subunit B1 CTD phosphatase RPAP2, putative; TAIR: AT5G26760.2 RNA polymerase II subunit B1 CTD phosphatase RPAP2-like protein; Swiss-Prot: sp|F4K1B1|RPAP2_ARATH Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog; TrEMBL-Plants: tr|I1JGF0|I1JGF0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0282700 | 3 | ||
– | RNA polymerase II subunit B1 CTD phosphatase RPAP2, putative; TAIR: AT5G26760.2 RNA polymerase II subunit B1 CTD phosphatase RPAP2-like protein; Swiss-Prot: sp|F4K1B1|RPAP2_ARATH Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog; TrEMBL-Plants: tr|I1JGF0|I1JGF0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0282700 | 3 | ||
– | RNA polymerase II C-terminal domain phosphatase-like 1; TAIR: AT4G21670.1 C-terminal domain phosphatase-like 1; Swiss-Prot: sp|Q5YDB6|CPL1_ARATH RNA polymerase II C-terminal domain phosphatase-like 1; TrEMBL-Plants: tr|A0A0S3QZI5|A0A0S3QZI5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0054200 | 2 | ||
– | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.3 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A151SFP9|A0A151SFP9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0286500 | 2 | ||
– | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|V7BX02|V7BX02_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0287100 | 2 | ||
– | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A0L9TRV4|A0A0L9TRV4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0287100 | 2 | ||
– | RNA polymerase II subunit B1 CTD phosphatase RPAP2, putative; TAIR: AT5G26760.2 RNA polymerase II subunit B1 CTD phosphatase RPAP2-like protein; Swiss-Prot: sp|F4K1B1|RPAP2_ARATH Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog; TrEMBL-Plants: tr|I1JGF0|I1JGF0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0107900 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
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Biological process | Dephosphorylation of RNA polymerase II C-terminal domain | 1 | 10.00 |