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GO:0042721

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description TIM22 mitochondrial import inner membrane insertion complex
Full defintion A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12.
Subterm of

Relationships

The relationship of GO:0042721 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D
Elife. 2016 Aug 24; 5 (): .PMID: 27554484

The TIM22 complex mediates the import of hydrophobic carrier proteins into the mitochondrial inner membrane. While the TIM22 machinery has been well characterised in yeast, the human complex remains poorly characterised. Here, we identify Tim29 (C19orf52) as a novel, metazoan-specific subunit of the human TIM22 complex. The protein is integrated into the mitochondrial inner membrane with it's C-terminus exposed to the intermembrane space. Tim29 is required for the stability of the TIM22 complex and functions in the assembly of hTim22. Furthermore, Tim29 contacts the Translocase of the Outer Mitochondrial Membrane, TOM complex, enabling a mechanism for transport of hydrophobic carrier substrates across the aqueous intermembrane space. Identification of Tim29 highlights the significance of analysing mitochondrial import systems across phylogenetic boundaries, which can reveal novel components and mechanisms in higher organisms.

Associated Lotus transcripts 7

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi1g1v0021500.1
– Mitochondrial import inner membrane translocase subunit TIM22; TAIR: AT5G55510.1 Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein; Swiss-Prot: sp|Q6NKU9|TI223_ARATH Mitochondrial import inner membrane translocase subunit TIM22-3; TrEMBL-Plants: tr|I3T6N2|I3T6N2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0021500
GO terms
2
LotjaGi1g1v0302500.1
– Mitochondrial import inner membrane translocase subunit TIM22; TAIR: AT5G24650.1 Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein; Swiss-Prot: sp|Q6NKU9|TI223_ARATH Mitochondrial import inner membrane translocase subunit TIM22-3; TrEMBL-Plants: tr|I1JYE9|I1JYE9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0302500
GO terms
2
LotjaGi1g1v0724800.1
– Mitochondrial import inner membrane translocase subunit Tim22; TAIR: AT2G42210.1 Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein; Swiss-Prot: sp|O48528|OP163_ARATH Outer envelope pore protein 16-3, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I3T3A7|I3T3A7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0724800
GO terms
2
LotjaGi1g1v0724800.2
– Mitochondrial import inner membrane translocase subunit Tim22; TAIR: AT2G42210.1 Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein; Swiss-Prot: sp|O48528|OP163_ARATH Outer envelope pore protein 16-3, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I3T3A7|I3T3A7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0724800
GO terms
2
LotjaGi3g1v0542300.1
– Mitochondrial import inner membrane translocase subunit TIM22; TAIR: AT3G10110.1 Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein; Swiss-Prot: sp|A2RVP7|TI221_ARATH Mitochondrial import inner membrane translocase subunit TIM22-1; TrEMBL-Plants: tr|I3SGH6|I3SGH6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0542300
GO terms
2
LotjaGi5g1v0250400.1
– Mitochondrial import inner membrane translocase subunit tim22; TAIR: AT3G62880.1 Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein; Swiss-Prot: sp|Q9LZH8|OP164_ARATH Outer envelope pore protein 16-4, chloroplastic; TrEMBL-Plants: tr|I3T2W3|I3T2W3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0250400
GO terms
2
LotjaGi5g1v0250400.2
– Mitochondrial import inner membrane translocase subunit tim22; TAIR: AT3G62880.1 Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein; Swiss-Prot: sp|Q9LZH8|OP164_ARATH Outer envelope pore protein 16-4, chloroplastic; TrEMBL-Plants: tr|I3T2W3|I3T2W3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0250400
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0045039
Biological process Protein import into mitochondrial inner membrane 1 14.29