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IPR000156

Source: InterPro

Description

IPR000156 is a Ran binding domain.

<p>Ran is an evolutionary conserved member of the Ras superfamily that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran Binding Protein 1 (RanBP1) has guanine nucleotide dissociation inhibitory activity, specific for the GTP form of Ran and also functions to stimulate Ran GTPase activating protein(GAP)-mediated GTP hydrolysis by Ran. RanBP1 contributes to maintaining the gradient of RanGTP across the nuclear envelope high (GDI activity) or the cytoplasmic levels of RanGTP low (GAP cofactor) [[cite:PUB00007086]].</p> <p>All RanBP1 proteins contain an approx 150 amino acid residue Ran binding domain. Ran BP1 binds directly to RanGTP with high affinity. There are four sites of contact between Ran and the Ran binding domain. One of these involves binding of the C-terminal segment of Ran to a groove on the Ran binding domain that is analogous to the surface utilised in the EVH1-peptide interaction [[cite:PUB00007092]]. Nup358 contains four Ran binding domains. The structure of the first of these is known [[cite:PUB00006171]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0046907
Biological process Intracellular transport The directed movement of substances within a cell.
Subterm of

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
Lj0g3v0246169.1
– PREDICTED: brefeldin A resistance protein-like [Glycine max] gi|356556006|ref|XP_003546318.1|
Domains
13
Lj3g3v0139590.1
– PREDICTED: brefeldin A resistance protein-like [Glycine max] gi|356556006|ref|XP_003546318.1|
Domains
11
Lj5g3v1903690.1
– PREDICTED: ran-binding protein 1 homolog b-like [Glycine max] gi|356576095|ref|XP_003556169.1|
Domains
11
LotjaGi2g1v0431100.1
– Nuclear pore complex protein Nup50; TAIR: AT4G11790.1 Pleckstrin homology (PH) domain superfamily protein; Swiss-Prot: sp|Q9JIH2|NUP50_MOUSE Nuclear pore complex protein Nup50; TrEMBL-Plants: tr|A0A061G427|A0A061G427_THECC Pleckstrin domain superfamily protein isoform 1; Found in the gene: LotjaGi2g1v0431100
Domains
11
LotjaGi2g1v0431100.2
– Nuclear pore complex protein Nup50; TAIR: AT4G11790.1 Pleckstrin homology (PH) domain superfamily protein; Swiss-Prot: sp|Q9JIH2|NUP50_MOUSE Nuclear pore complex protein Nup50; TrEMBL-Plants: tr|A0A061G427|A0A061G427_THECC Pleckstrin domain superfamily protein isoform 1; Found in the gene: LotjaGi2g1v0431100
Domains
11
LotjaGi2g1v0431100.3
– Nuclear pore complex protein Nup50; TAIR: AT4G11790.1 Pleckstrin homology (PH) domain superfamily protein; Swiss-Prot: sp|Q9JIH2|NUP50_MOUSE Nuclear pore complex protein Nup50; TrEMBL-Plants: tr|I1LGI3|I1LGI3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0431100
Domains
11
LotjaGi2g1v0431100.4
– Nuclear pore complex protein Nup50; TAIR: AT4G11790.1 Pleckstrin homology (PH) domain superfamily protein; Swiss-Prot: sp|Q9JIH2|NUP50_MOUSE Nuclear pore complex protein Nup50; TrEMBL-Plants: tr|I1LGI3|I1LGI3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0431100
Domains
11
LotjaGi3g1v0015500.1
– Ran-binding protein 1 domain-containing; TAIR: AT1G52380.1 NUP50 (Nucleoporin 50 kDa) protein; Swiss-Prot: sp|Q9C829|NU50A_ARATH Nuclear pore complex protein NUP50A; TrEMBL-Plants: tr|A0A0B2NU93|A0A0B2NU93_GLYSO E3 SUMO-protein ligase RanBP2; Found in the gene: LotjaGi3g1v0015500
Domains
13
LotjaGi5g1v0286500.1
– RAN BINDING protein 1; TAIR: AT5G58590.1 RAN binding protein 1; Swiss-Prot: sp|P92985|RBP1C_ARATH Ran-binding protein 1 homolog c; TrEMBL-Plants: tr|I1NH59|I1NH59_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0286500
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 11.11