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IPR000245 is a V-ATPase proteolipid subunit.
<p>This entry represents the 16kDa proteolipid subunit c that is part of the V0 complex of V-ATPase in eukaryotic organelles and in certain bacteria. There are three proteolipid subunits (known as c, c' and c'' in yeast) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [[cite:PUB00020629], [cite:PUB00020631]].</p> <p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p> <p>V-ATPases (also known as V1V0-ATPase or vacuolar ATPase) are found in the eukaryotic endomembrane system, and in the plasma membrane of prokaryotes and certain specialised eukaryotic cells. V-ATPases hydrolyse ATP to drive a proton pump, and are involved in a variety of vital intra-and inter-cellular processes such as receptor mediated endocytosis, protein trafficking, active transport of metabolites, homeostasis and neurotransmitter release [[cite:PUB00020609]]. V-ATPases are composed of two linked complexes: the V1 complex (subunits A-H) contains the catalytic core that hydrolyses ATP, while the V0 complex (subunits a, c, c', c'', d) forms the membrane-spanning pore. V-ATPases may have an additional role in membrane fusion through binding to t-SNARE proteins [[cite:PUB00020608]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Proton transmembrane transporter activity | Enables the transfer of a proton from one side of a membrane to the other. | ||
| Cellular component | Proton-transporting V-type ATPase, V0 domain | A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. | ||
| Biological process | Proton transmembrane transport | The directed movement of a proton across a membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | V-type proton ATPase 16 kDa proteolipid subunit c4 [Medicago truncatula] gi|357483701|ref|XP_003612137.1| | 14 | ||
| – | V-type proton ATPase 16 kDa proteolipid subunit c4 [Medicago truncatula] gi|357483701|ref|XP_003612137.1| | 14 | ||
| – | V-type proton ATPase 16 kDa proteolipid subunit c1/c3/c5 [Medicago truncatula] gi|357473589|ref|XP_003607079.1| | 14 | ||
| – | ATPase, F0/V0 complex, subunit C protein [Theobroma cacao] gi|508784156|gb|EOY31412.1| | 12 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P59229|VATL4_ARATH V-type proton ATPase subunit c4; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0158500 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G19910.1 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|Q43434|VATL_GOSHI V-type proton ATPase 16 kDa proteolipid subunit; TrEMBL-Plants: tr|A0A0B0PYA5|A0A0B0PYA5_GOSAR V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0158500 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.2 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|O22552|VATL_VIGRR V-type proton ATPase 16 kDa proteolipid subunit; TrEMBL-Plants: tr|A0A0D3DHQ4|A0A0D3DHQ4_BRAOL V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0158500 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|A0A0D3A1X3|A0A0D3A1X3_BRAOL Uncharacterized protein; Found in the gene: LotjaGi1g1v0158500 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P59229|VATL4_ARATH V-type proton ATPase subunit c4; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0562500 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.2 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|F4HZ57|F4HZ57_ARATH V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0562500 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.2 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|O22552|VATL_VIGRR V-type proton ATPase 16 kDa proteolipid subunit; TrEMBL-Plants: tr|A0A0D3DHQ4|A0A0D3DHQ4_BRAOL V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0562500 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G19910.1 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|A0A0B0PYA5|A0A0B0PYA5_GOSAR V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0562500 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P59229|VATL4_ARATH V-type proton ATPase subunit c4; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi2g1v0383100 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.2 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|O22552|VATL_VIGRR V-type proton ATPase 16 kDa proteolipid subunit; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi2g1v0383100 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P59229|VATL4_ARATH V-type proton ATPase subunit c4; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi2g1v0383100 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT1G19910.1 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|A0A0B0PYA5|A0A0B0PYA5_GOSAR V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi2g1v0383100 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT2G16510.1 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi3g1v0515300 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT4G34720.2 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|I1LPX0|I1LPX0_SOYBN V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi3g1v0515300 | 17 | ||
| – | V-type proton ATPase proteolipid subunit; TAIR: AT2G25610.2 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|Q9SLA2|VATO2_ARATH V-type proton ATPase subunit c''2; TrEMBL-Plants: tr|I3S4U9|I3S4U9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0061800 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18178 | CDD | 1 | 5.26 |