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Field | Value |
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Namespace | Cellular component |
Short description | Proton-transporting V-type ATPase, V0 domain |
Full defintion | A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. |
Subterm of |
The relationship of GO:0033179 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0033179, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | mah |
ISBN | Molecular Cell Biology · Macmillan, 2004 · 1096 pages The fifth edition provides an authoritative and comprehensive vision of molecular biology today. It presents developments in cell birth, lineage and death, expanded coverage of signaling systems and of metabolism and movement of lipids. |
PMID | The V-type H+ ATPase: molecular structure and function, physiological roles and regulation. J Exp Biol. 2006 Feb; 209 (Pt 4): 577–89.PMID: 16449553 It was nearly 30 years before the V-type H+ ATPase was admitted to the small circle of bona fide transport ATPases alongside F-type and P-type ATPases. The V-type H+ ATPase is an ATP-driven enzyme that transforms the energy of ATP hydrolysis to electrochemical potential differences of protons across diverse biological membranes via the primary active transport of H+. In turn, the transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. For example, expression of Cl- channels or transporters next to the V-type H+ ATPase in vacuoles of plants and fungi and in lysosomes of animals brings about the acidification of the endosomal compartment, and the expression of the H+/neurotransmitter antiporter next to the V-type H+ ATPase concentrates neurotransmitters in synaptic vesicles. First found in association with endosomal membranes, the V-type H+ ATPase is now also found in increasing examples of plasma membranes where the proton pump energizes transport across cell membranes and entire epithelia. The molecular details reveal up to 14 protein subunits arranged in (i) a cytoplasmic V1 complex, which mediates the hydrolysis of ATP, and (ii) a membrane-embedded V0 complex, which translocates H+ across the membrane. Clever experiments have revealed the V-type H+ ATPase as a molecular motor akin to F-type ATPases. The hydrolysis of ATP turns a rotor consisting largely of one copy of subunits D and F of the V1 complex and a ring of six or more copies of subunit c of the V0 complex. The rotation of the ring is thought to deliver H+ from the cytoplasmic to the endosomal or extracellular side of the membrane, probably via channels formed by subunit a. The reversible dissociation of V1 and V0 complexes is one mechanism of physiological regulation that appears to be widely conserved from yeast to animal cells. Other mechanisms, such as subunit-subunit interactions or interactions of the V-type H+ ATPase with other proteins that serve physiological regulation, remain to be explored. Some diseases can now be attributed to genetic alterations of specific subunits of the V-type H+ ATPase. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356547204|ref|XP_003542006.1| | 3 | ||
– | PREDICTED: vacuolar proton ATPase a1-like [Cicer arietinum] gi|502082366|ref|XP_004487144.1| | 3 | ||
– | PREDICTED: V-type proton ATPase subunit e-like [Cicer arietinum] gi|502128904|ref|XP_004500119.1| | 3 | ||
– | PREDICTED: vacuolar proton ATPase a1-like [Cicer arietinum] gi|502082366|ref|XP_004487144.1| | 3 | ||
– | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356558433|ref|XP_003547511.1| | 3 | ||
– | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356558433|ref|XP_003547511.1| | 3 | ||
– | V-type proton ATPase 16 kDa proteolipid subunit c4 [Medicago truncatula] gi|357483701|ref|XP_003612137.1| | 3 | ||
– | 3 | |||
– | PREDICTED: V-type proton ATPase subunit d2-like isoform 1 [Glycine max] gi|356531794|ref|XP_003534461.1| | 3 | ||
– | V-type proton ATPase 16 kDa proteolipid subunit c4 [Medicago truncatula] gi|357483701|ref|XP_003612137.1| | 3 | ||
– | PREDICTED: V-type proton ATPase subunit d2-like isoform 2 [Glycine max] gi|356531796|ref|XP_003534462.1| | 3 | ||
– | Vacuolar ATPase subunit e-like [Mesembryanthemum crystallinum] gi|26986112|emb|CAD27522.1| | 3 | ||
– | CM0216.490.nc [Lotus japonicus] gi|164605517|dbj|BAF98583.1| | 3 | ||
– | CM0216.490.nc [Lotus japonicus] gi|164605517|dbj|BAF98583.1| | 3 | ||
– | CM0216.490.nc [Lotus japonicus] gi|164605517|dbj|BAF98583.1| | 3 | ||
– | V-type proton ATPase 116 kDa subunit a isoform [Medicago truncatula] gi|357473431|ref|XP_003607000.1| | 3 | ||
– | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356542569|ref|XP_003539739.1| | 3 | ||
– | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356542569|ref|XP_003539739.1| | 3 | ||
– | V-type proton ATPase 16 kDa proteolipid subunit c1/c3/c5 [Medicago truncatula] gi|357473589|ref|XP_003607079.1| | 3 | ||
– | ATPase, F0/V0 complex, subunit C protein [Theobroma cacao] gi|508784156|gb|EOY31412.1| | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P59229|VATL4_ARATH V-type proton ATPase subunit c4; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0158500 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G19910.1 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|Q43434|VATL_GOSHI V-type proton ATPase 16 kDa proteolipid subunit; TrEMBL-Plants: tr|A0A0B0PYA5|A0A0B0PYA5_GOSAR V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0158500 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.2 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|O22552|VATL_VIGRR V-type proton ATPase 16 kDa proteolipid subunit; TrEMBL-Plants: tr|A0A0D3DHQ4|A0A0D3DHQ4_BRAOL V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0158500 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|A0A0D3A1X3|A0A0D3A1X3_BRAOL Uncharacterized protein; Found in the gene: LotjaGi1g1v0158500 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT4G39080.1 vacuolar proton ATPase A3; Swiss-Prot: sp|Q8W4S4|VHAA3_ARATH V-type proton ATPase subunit a3; TrEMBL-Plants: tr|A0A151RQM9|A0A151RQM9_CAJCA V-type proton ATPase subunit a; Found in the gene: LotjaGi1g1v0424500 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G21410.1 vacuolar proton ATPase A2; Swiss-Prot: sp|Q9SJT7|VHAA2_ARATH V-type proton ATPase subunit a2; TrEMBL-Plants: tr|I1K7M8|I1K7M8_SOYBN V-type proton ATPase subunit a; Found in the gene: LotjaGi1g1v0424500 | 3 | ||
– | V-type proton ATPase subunit d; TAIR: AT3G28715.1 ATPase, V0/A0 complex, subunit C/D; Swiss-Prot: sp|Q9LHA4|VA0D2_ARATH V-type proton ATPase subunit d2; TrEMBL-Plants: tr|I1L5Z7|I1L5Z7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0498600 | 3 | ||
– | V-type proton ATPase subunit d; TAIR: AT3G28715.2 ATPase, V0/A0 complex, subunit C/D; Swiss-Prot: sp|Q9LHA4|VA0D2_ARATH V-type proton ATPase subunit d2; TrEMBL-Plants: tr|I1L5Z7|I1L5Z7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0498600 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P59229|VATL4_ARATH V-type proton ATPase subunit c4; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0562500 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.2 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|F4HZ57|F4HZ57_ARATH V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0562500 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.2 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|O22552|VATL_VIGRR V-type proton ATPase 16 kDa proteolipid subunit; TrEMBL-Plants: tr|A0A0D3DHQ4|A0A0D3DHQ4_BRAOL V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0562500 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G19910.1 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|A0A0B0PYA5|A0A0B0PYA5_GOSAR V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi1g1v0562500 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|I1LR08|I1LR08_SOYBN V-type proton ATPase subunit a; Found in the gene: LotjaGi2g1v0364600 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A1J7GFZ0|A0A1J7GFZ0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0364600 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A1J7GFZ0|A0A1J7GFZ0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0364600 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A1J7GFZ0|A0A1J7GFZ0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0364600 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A0R0H303|A0A0R0H303_SOYBN V-type proton ATPase subunit a; Found in the gene: LotjaGi2g1v0364600 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P59229|VATL4_ARATH V-type proton ATPase subunit c4; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi2g1v0383100 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.2 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|O22552|VATL_VIGRR V-type proton ATPase 16 kDa proteolipid subunit; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi2g1v0383100 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G75630.1 vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4; Swiss-Prot: sp|P59229|VATL4_ARATH V-type proton ATPase subunit c4; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi2g1v0383100 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT1G19910.1 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|A0A0B0PYA5|A0A0B0PYA5_GOSAR V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi2g1v0383100 | 3 | ||
– | V-type proton ATPase subunit d; TAIR: AT3G28710.1 ATPase, V0/A0 complex, subunit C/D; Swiss-Prot: sp|Q9LJI5|VA0D1_ARATH V-type proton ATPase subunit d1; TrEMBL-Plants: tr|A0A0B2PV76|A0A0B2PV76_GLYSO V-type proton ATPase subunit d2; Found in the gene: LotjaGi2g1v0408800_LC | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|K7M9K9|K7M9K9_SOYBN V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0273900 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A0S3SGJ3|A0A0S3SGJ3_PHAAN V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0273900 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A0S3SGJ3|A0A0S3SGJ3_PHAAN V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0273900 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|V7BYX1|V7BYX1_PHAVU V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0273900 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT4G39080.1 vacuolar proton ATPase A3; Swiss-Prot: sp|Q8W4S4|VHAA3_ARATH V-type proton ATPase subunit a3; TrEMBL-Plants: tr|B0BL94|B0BL94_LOTJA V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0512800 | 3 | ||
– | V-type proton ATPase subunit a; TAIR: AT4G39080.1 vacuolar proton ATPase A3; Swiss-Prot: sp|Q8W4S4|VHAA3_ARATH V-type proton ATPase subunit a3; TrEMBL-Plants: tr|B0BL94|B0BL94_LOTJA V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0512800 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT2G16510.1 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|A0A078I7D8|A0A078I7D8_BRANA V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi3g1v0515300 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT4G34720.2 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|P0DH92|VATL1_ARATH V-type proton ATPase subunit c1; TrEMBL-Plants: tr|I1LPX0|I1LPX0_SOYBN V-type proton ATPase proteolipid subunit; Found in the gene: LotjaGi3g1v0515300 | 3 | ||
– | V-type proton ATPase proteolipid subunit; TAIR: AT2G25610.2 ATPase, F0/V0 complex, subunit C protein; Swiss-Prot: sp|Q9SLA2|VATO2_ARATH V-type proton ATPase subunit c''2; TrEMBL-Plants: tr|I3S4U9|I3S4U9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0061800 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Proton transmembrane transport | 1 | 1.96 |