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IPR000261 is a EH domain.
<p>The EH (for Eps15 Homology) domain is a protein-protein interaction module of approximately 95 residues which was originally identified as a repeated sequence present in three copies at the N terminus of the tyrosine kinase substrates Eps15 and Eps15R [[cite:PUB00007075], [cite:PUB00007076]]. The EH domain was subsequently found in several proteins implicated in endocytosis, vesicle transport and signal transduction in organisms ranging from yeast to mammals. EH domains are present in one to three copies and they may include calcium-binding domains of the EF-hand type [[cite:PUB00007077], [cite:PUB00007078]]. Eps15 is divided into three domains: domain I contains signatures of a regulatory domain, including a candidate tyrosine phosphorylation site and EF-hand-type calcium-binding domains, domain II presents the characteristic heptad repeats of coiled-coil rod-like proteins, and domain III displays a repeated aspartic acid-proline-phenylalanine motif similar to a consensus sequence of several methylases [[cite:PUB00006290]].</p> <p>EH domains have been shown to bind specifically but with moderate affinity to peptides containing short, unmodified motifs through predominantly hydrophobic interactions. The target motifs are divided into three classes: class I consists of the concensus Asn-Pro-Phe (NPF) sequence; class II consists of aromatic and hydrophobic di- and tripeptide motifs, including the Phe-Trp (FW), Trp-Trp (WW), and Ser-Trp-Gly (SWG) motifs; and class III contains the His-(Thr/Ser)-Phe motif (HTF/HSF) [[cite:PUB00007079], [cite:PUB00007080]]. The structure of several EH domains has been solved by NMR spectroscopy. The fold consists of two helix-loop-helix characteristic of EF-hand domains, connected by a short antiparallel β-sheet. The target peptide is bound in a hydrophobic pocket between two α helices. Sequence analysis and structural data indicate that not all the EF-hands are capable of binding calcium because of substitutions of the calcium-liganding residues in the loop [[cite:PUB00007081], [cite:PUB00007082], [cite:PUB00007084]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Epidermal growth factor receptor substrate 15-like protein [Medicago truncatula] gi|357495659|ref|XP_003618118.1| | 12 | ||
| – | PREDICTED: epidermal growth factor receptor substrate 15-like isoform X1 [Cicer arietinum] gi|502131051|ref|XP_004500858.1| | 17 | ||
| – | PREDICTED: EH domain-containing protein 3-like [Cicer arietinum] gi|502099243|ref|XP_004491428.1| | 12 | ||
| – | PREDICTED: EH domain-containing protein 1-like [Glycine max] gi|356522037|ref|XP_003529656.1| | 24 | ||
| – | PREDICTED: EH domain-containing protein 3-like [Cicer arietinum] gi|502099243|ref|XP_004491428.1| | 12 | ||
| – | PREDICTED: EH domain-containing protein 3-like [Cicer arietinum] gi|502099243|ref|XP_004491428.1| | 12 | ||
| – | Epidermal growth factor receptor substrate 15-like protein [Medicago truncatula] gi|357495659|ref|XP_003618118.1| | 14 | ||
| – | PREDICTED: EH domain-containing protein 1-like [Glycine max] gi|356557953|ref|XP_003547274.1| | 24 | ||
| – | Calcium-binding EF hand-like protein; TAIR: AT1G20760.1 Calcium-binding EF hand family protein; Swiss-Prot: sp|Q9HGL2|YHLA_SCHPO Uncharacterized calcium-binding protein C800.10c; TrEMBL-Plants: tr|I1M635|I1M635_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0001100 | 16 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|G7K8N7|G7K8N7_MEDTR Calcium-binding EF hand protein; Found in the gene: LotjaGi1g1v0024800 | 26 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|A0A0L9UVF7|A0A0L9UVF7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0024800 | 26 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|I1JJC9|I1JJC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0024800 | 25 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|A0A1J7HUL5|A0A1J7HUL5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0024800 | 23 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|G7K8N7|G7K8N7_MEDTR Calcium-binding EF hand protein; Found in the gene: LotjaGi1g1v0024800 | 26 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|A0A151U2E6|A0A151U2E6_CAJCA EH domain-containing protein 1; Found in the gene: LotjaGi1g1v0024800 | 25 | ||
| – | Calcium-binding EF hand protein; TAIR: AT1G20760.1 Calcium-binding EF hand family protein; Swiss-Prot: sp|B3LF48|EHD2_ARATH EH domain-containing protein 2; TrEMBL-Plants: tr|A0A0B2QIP4|A0A0B2QIP4_GLYSO Putative calcium-binding protein; Found in the gene: LotjaGi1g1v0567200 | 17 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|G7K8N7|G7K8N7_MEDTR Calcium-binding EF hand protein; Found in the gene: LotjaGi4g1v0009500 | 27 | ||
| – | EH domain-containing protein 1; TAIR: AT4G05520.1 EPS15 homology domain 2; Swiss-Prot: sp|B3LF48|EHD2_ARATH EH domain-containing protein 2; TrEMBL-Plants: tr|A0A0B2R9H2|A0A0B2R9H2_GLYSO EH domain-containing protein 1; Found in the gene: LotjaGi4g1v0009700 | 28 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|I1N0J5|I1N0J5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0154400 | 26 | ||
| – | EH domain-containing protein 1; TAIR: AT3G20290.1 EPS15 homology domain 1; Swiss-Prot: sp|Q94CF0|EHD1_ARATH EH domain-containing protein 1; TrEMBL-Plants: tr|A0A199W5Q7|A0A199W5Q7_ANACO EH domain-containing protein 1; Found in the gene: LotjaGi6g1v0154400 | 23 | ||
| – | EH domain-containing protein 1; TAIR: AT4G05520.1 EPS15 homology domain 2; Swiss-Prot: sp|B3LF48|EHD2_ARATH EH domain-containing protein 2; TrEMBL-Plants: tr|I1MFL9|I1MFL9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0288500 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd09913 | CDD | 1 | 4.76 |