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IPR000337 is a GPCR, family 3.
<p>G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [[cite:PUB00053635]]. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence [[cite:PUB00004961]]. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [[cite:PUB00004961], [cite:PUB00063577], [cite:PUB00063578], [cite:PUB00063579], [cite:PUB00063580]]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice [[cite:PUB00053635]]. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [[cite:PUB00063816]].</p> <p>GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length [[cite:PUB00036049]]. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [[cite:PUB00004309], [cite:PUB00004161], [cite:PUB00036050], [cite:PUB00007343]]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. | ||
| Biological process | G protein-coupled receptor signaling pathway | A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glutamate-gated kainate-type ion channel receptor subunit GluR5 [Medicago truncatula] gi|357467129|ref|XP_003603849.1| | 33 | ||
| – | PREDICTED: glutamate receptor 3.6-like [Glycine max] gi|356529661|ref|XP_003533407.1| | 30 | ||
| – | PREDICTED: glutamate receptor 3.2-like [Glycine max] gi|356553421|ref|XP_003545055.1| | 9 | ||
| – | Glutamate receptor; TAIR: AT4G35290.1 glutamate receptor 2; Swiss-Prot: sp|Q93YT1|GLR32_ARATH Glutamate receptor 3.2; TrEMBL-Plants: tr|I1M634|I1M634_SOYBN Glutamate receptor; Found in the gene: LotjaGi1g1v0001000 | 22 | ||
| – | Glutamate receptor; TAIR: AT1G42540.1 glutamate receptor 3.3; Swiss-Prot: sp|Q9C8E7|GLR33_ARATH Glutamate receptor 3.3; TrEMBL-Plants: tr|A0A1J7I836|A0A1J7I836_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0567700 | 33 | ||
| – | Glutamate receptor; TAIR: AT2G32400.1 glutamate receptor 5; Swiss-Prot: sp|Q9SDQ4|GLR37_ARATH Glutamate receptor 3.7; TrEMBL-Plants: tr|A0A0R0H9K3|A0A0R0H9K3_SOYBN Glutamate receptor; Found in the gene: LotjaGi3g1v0189800 | 26 | ||
| – | Glutamate receptor; TAIR: AT3G51480.1 glutamate receptor 3.6; Swiss-Prot: sp|Q84W41|GLR36_ARATH Glutamate receptor 3.6; TrEMBL-Plants: tr|I1L4P7|I1L4P7_SOYBN Glutamate receptor; Found in the gene: LotjaGi4g1v0134800 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd13686 | CDD | 1 | 14.29 |