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Metabotropic glutamate GPCR signature
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. | ||
| Biological process | G protein-coupled receptor signaling pathway | A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glutamate-gated kainate-type ion channel receptor subunit GluR5 [Medicago truncatula] gi|357467129|ref|XP_003603849.1| | 33 | ||
| – | PREDICTED: glutamate receptor 3.6-like [Glycine max] gi|356529661|ref|XP_003533407.1| | 30 | ||
| – | PREDICTED: glutamate receptor 3.2-like [Glycine max] gi|356553421|ref|XP_003545055.1| | 9 | ||
| – | Glutamate receptor; TAIR: AT4G35290.1 glutamate receptor 2; Swiss-Prot: sp|Q93YT1|GLR32_ARATH Glutamate receptor 3.2; TrEMBL-Plants: tr|I1M634|I1M634_SOYBN Glutamate receptor; Found in the gene: LotjaGi1g1v0001000 | 22 | ||
| – | Glutamate receptor; TAIR: AT1G42540.1 glutamate receptor 3.3; Swiss-Prot: sp|Q9C8E7|GLR33_ARATH Glutamate receptor 3.3; TrEMBL-Plants: tr|A0A1J7I836|A0A1J7I836_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0567700 | 33 | ||
| – | Glutamate receptor; TAIR: AT2G32400.1 glutamate receptor 5; Swiss-Prot: sp|Q9SDQ4|GLR37_ARATH Glutamate receptor 3.7; TrEMBL-Plants: tr|A0A0R0H9K3|A0A0R0H9K3_SOYBN Glutamate receptor; Found in the gene: LotjaGi3g1v0189800 | 26 | ||
| – | Glutamate receptor; TAIR: AT3G51480.1 glutamate receptor 3.6; Swiss-Prot: sp|Q84W41|GLR36_ARATH Glutamate receptor 3.6; TrEMBL-Plants: tr|I1L4P7|I1L4P7_SOYBN Glutamate receptor; Found in the gene: LotjaGi4g1v0134800 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd13686 | CDD | 1 | 14.29 |