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IPR000842 is a Phosphoribosyl pyrophosphate synthetase, conserved site.
<p>Phosphoribosyl pyrophosphate synthetase ([ec:2.7.6.1]) (PRib-PP synthetase) catalyses the formation of PRib-PP from ATP and ribose 5-phosphate. PRib-PP is then used in various biosynthetic pathways, for example in the formation of purines, pyrimidines, histidine and tryptophan. PRib-PP synthetase requires inorganic phosphate and magnesium ions for its stability and activity. In mammals, three isozymes of PRib-PP synthetase are found, while in yeast there are at least four isozymes. A very conserved region containing two conserved aspartic acid residues as well as a histidine has been suggested to be involved in binding divalent cations [[cite:PUB00002493]]. These residues are all potential ligands for a cation such as magnesium.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. | ||
| Molecular function | Ribose phosphate diphosphokinase activity | Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). | ||
| Biological process | Ribonucleoside monophosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. | ||
| Biological process | Cellular biosynthetic process | The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ribose-phosphate pyrophosphokinase 5, chloroplastic-like [Glycine max] gi|356504490|ref|XP_003521029.1| | 19 | ||
| – | PREDICTED: ribose-phosphate pyrophosphokinase 5, chloroplastic-like [Glycine max] gi|356504490|ref|XP_003521029.1| | 21 | ||
| – | Ribose-phosphate pyrophosphokinase [Medicago truncatula] gi|357476731|ref|XP_003608651.1| | 22 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT2G44530.1 Phosphoribosyltransferase family protein; Swiss-Prot: sp|Q9XG98|KPRS1_SPIOL Ribose-phosphate pyrophosphokinase 1; TrEMBL-Plants: tr|I1JMH4|I1JMH4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0073600 | 22 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT2G44530.1 Phosphoribosyltransferase family protein; Swiss-Prot: sp|O64888|KPRS5_ARATH Ribose-phosphate pyrophosphokinase 5, chloroplastic; TrEMBL-Plants: tr|I1JMH3|I1JMH3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0073600 | 22 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT2G44530.1 Phosphoribosyltransferase family protein; Swiss-Prot: sp|Q9XG98|KPRS1_SPIOL Ribose-phosphate pyrophosphokinase 1; TrEMBL-Plants: tr|I1JMH5|I1JMH5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0073600 | 22 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT2G44530.1 Phosphoribosyltransferase family protein; Swiss-Prot: sp|Q9XG98|KPRS1_SPIOL Ribose-phosphate pyrophosphokinase 1; TrEMBL-Plants: tr|A0A072TKF0|A0A072TKF0_MEDTR Ribose-phosphate pyrophosphokinase; Found in the gene: LotjaGi3g1v0073600 | 15 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT2G44530.1 Phosphoribosyltransferase family protein; Swiss-Prot: sp|Q9XG98|KPRS1_SPIOL Ribose-phosphate pyrophosphokinase 1; TrEMBL-Plants: tr|I1JMH5|I1JMH5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0073600 | 22 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT2G44530.1 Phosphoribosyltransferase family protein; Swiss-Prot: sp|Q9XG98|KPRS1_SPIOL Ribose-phosphate pyrophosphokinase 1; TrEMBL-Plants: tr|A0A072TKF0|A0A072TKF0_MEDTR Ribose-phosphate pyrophosphokinase; Found in the gene: LotjaGi3g1v0073600 | 17 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT2G44530.1 Phosphoribosyltransferase family protein; Swiss-Prot: sp|Q9XG98|KPRS1_SPIOL Ribose-phosphate pyrophosphokinase 1; TrEMBL-Plants: tr|A0A072TKF0|A0A072TKF0_MEDTR Ribose-phosphate pyrophosphokinase; Found in the gene: LotjaGi3g1v0073600 | 17 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT2G35390.2 Phosphoribosyltransferase family protein; Swiss-Prot: sp|Q42581|KPRS1_ARATH Ribose-phosphate pyrophosphokinase 1, chloroplastic; TrEMBL-Plants: tr|I3S2I7|I3S2I7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0189800 | 23 | ||
| – | Ribose-phosphate pyrophosphokinase; TAIR: AT1G32380.1 phosphoribosyl pyrophosphate (PRPP) synthase 2; Swiss-Prot: sp|Q9XG98|KPRS1_SPIOL Ribose-phosphate pyrophosphokinase 1; TrEMBL-Plants: tr|I3T7C1|I3T7C1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0189800 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06223 | CDD | 1 | 8.33 |