Description

IPR002355 is a Multicopper oxidase, copper-binding site.

<p>The entry represents a conserved region containing the Cu-binding site found in multicopper oxidases.</p> <p>Multicopper oxidases oxidise their substrate by accepting electrons at a mononuclear copper centre and transferring them to a trinuclear copper centre; dioxygen binds to the trinuclear centre and, following the transfer of four electrons, is reduced to two molecules of water [[cite:PUB00035913]]. There are three spectroscopically different copper centres found in multicopper oxidases: type 1 (or blue), type 2 (or normal) and type 3 (or coupled binuclear) [[cite:PUB00001382], [cite:PUB00001602]]. Multicopper oxidases consist of 2, 3 or 6 of these homologous domains, which also share homology to the cupredoxins azurin and plastocyanin. Structurally, these domains consist of a cupredoxin-like fold, a β-sandwich consisting of 7 strands in 2 β-sheets, arranged in a Greek-key β-barrel [[cite:PUB00011817]]. Multicopper oxidases include:</p> <ul> <li>Ceruloplasmin ([ec:1.16.3.1]) (ferroxidase), a 6-domain enzyme found in the serum of mammals and birds that oxidizes different inorganic and organic substances; exhibits internal sequence homology that appears to have evolved from the triplication of a Cu-binding domain similar to that of laccase and ascorbate oxidase.</li> <li>Laccase ([ec:1.10.3.2]) (urishiol oxidase), a 3-domain enzyme found in fungi and plants, which oxidizes different phenols and diamines. CueO is a laccase found in Escherichia coli that is involved in copper-resistance [[cite:PUB00011817]].</li> <li>Ascorbate oxidase ([ec:1.10.3.3]), a 3-domain enzyme found in higher plants.</li> <li>Nitrite reductase ([ec:1.7.2.1]), a 2-domain enzyme containing type-1 and type-2 copper centres [[cite:PUB00035911], [cite:PUB00035912]].</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 63

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: