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IPR004790 is a Isocitrate dehydrogenase NADP-dependent.
<p>Isocitrate dehydrogenase (IDH) [[cite:PUB00004691], [cite:PUB00002669]] is an important enzyme of carbohydrate metabolism which catalyses the oxidative decarboxylation of isocitrate into alpha-ketoglutarate. IDH is either dependent on NAD<sup>+</sup> ([ec:1.1.1.41]) or on NADP<sup>+</sup> ([ec:1.1.1.42]). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD<sup>+</sup>-dependent, the other NADP<sup>+</sup>-dependent), while the third one (also NADP<sup>+</sup>-dependent) is cytoplasmic. In Escherichia coli the activity of a NADP<sup>+</sup>-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.</p> <p>The eukaryotic, NADP-dependent isocitrate dehydrogenases, are defined by this family that includes cytosolic, mitochondrial, and chloroplast enzymes, as well as bacterial proteins. This family differs considerably from other isocitrate dehydrogenases that are included in a different group together with 3-isopropylmalate dehydrogenases and tartrate dehydrogenases.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Isocitrate dehydrogenase (NADP+) activity | Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. | ||
| Biological process | Isocitrate metabolic process | The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: isocitrate dehydrogenase [NADP] gi|356513947|ref|XP_003525669.1| | 8 | ||
| – | PREDICTED: isocitrate dehydrogenase [NADP] gi|502096593|ref|XP_004490788.1| | 11 | ||
| – | PREDICTED: isocitrate dehydrogenase [NADP] gi|356513947|ref|XP_003525669.1| | 11 | ||
| – | NADP-dependent isocitrate dehydrogenase [Glycine max] gi|351721946|ref|NP_001236203.1| | 11 | ||
| – | Isocitrate dehydrogenase [NADP]; TAIR: AT1G65930.1 cytosolic NADP+-dependent isocitrate dehydrogenase; Swiss-Prot: sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0R0GQK7|A0A0R0GQK7_SOYBN Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi1g1v0219400 | 12 | ||
| – | Isocitrate dehydrogenase [NADP]; TAIR: AT1G65930.1 cytosolic NADP+-dependent isocitrate dehydrogenase; Swiss-Prot: sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|C6T857|C6T857_SOYBN Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi1g1v0219400 | 12 | ||
| – | Isocitrate dehydrogenase [NADP]; TAIR: AT1G65930.1 cytosolic NADP+-dependent isocitrate dehydrogenase; Swiss-Prot: sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|C6T857|C6T857_SOYBN Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi1g1v0219400 | 12 | ||
| – | Isocitrate dehydrogenase [NADP]; TAIR: AT1G54340.1 isocitrate dehydrogenase; Swiss-Prot: sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0B2QN79|A0A0B2QN79_GLYSO Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi3g1v0130600 | 12 | ||
| – | Isocitrate dehydrogenase [NADP]; TAIR: AT1G54340.1 isocitrate dehydrogenase; Swiss-Prot: sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0R0IMT3|A0A0R0IMT3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0130600 | 12 | ||
| – | Isocitrate dehydrogenase [NADP]; TAIR: AT1G54340.1 isocitrate dehydrogenase; Swiss-Prot: sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0R0IMT3|A0A0R0IMT3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0130600 | 12 | ||
| – | Isocitrate dehydrogenase [NADP]; TAIR: AT1G54340.1 isocitrate dehydrogenase; Swiss-Prot: sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0B2QN79|A0A0B2QN79_GLYSO Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi3g1v0130600 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00127 | TIGRFAM | 1 | 9.09 |