Description

IPR024084 is a Isopropylmalate dehydrogenase-like domain.

<p>The isocitrate and isopropylmalate dehydrogenases family includes isocitrate dehydrogenase (IDH), 3-isopropylmalate dehydrogenase (IMDH) and tartrate dehydrogenase.</p> <p>IDH is an important enzyme of carbohydrate metabolism which catalyses the oxidative decarboxylation of isocitrate into alpha-ketoglutarate [[cite:PUB00004691], [cite:PUB00002669]]. IDH is either dependent on NAD⁺ ([ec:1.1.1.41]) or on NADP⁺ ([ec:1.1.1.42]). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD⁺-dependent, the other NADP⁺-dependent), while the third one (also NADP⁺-dependent) is cytoplasmic. In Escherichia coli, the activity of a NADP⁺-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.</p> <p>IMDH ([ec:1.1.1.85]) catalyses the third step in the biosynthesis of leucine in bacteria and fungi, the oxidative decarboxylation of 3-isopropylmalate into 2-oxo-4-methylvalerate [[cite:PUB00003276], [cite:PUB00005036]].</p> <p>This entry represents a structural domain found in all types of isocitrate dehydrogenase, and in isopropylmalate dehydrogenase and tartrate dehydrogenase. The crystal structure of Escherichia coli isopropylmalate dehydrogenase has been described [[cite:PUB00022856]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 24

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: