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IPR024084

Description

IPR024084 is a Isopropylmalate dehydrogenase-like domain.

<p>The isocitrate and isopropylmalate dehydrogenases family includes isocitrate dehydrogenase (IDH), 3-isopropylmalate dehydrogenase (IMDH) and tartrate dehydrogenase.</p> <p>IDH is an important enzyme of carbohydrate metabolism which catalyses the oxidative decarboxylation of isocitrate into alpha-ketoglutarate [[cite:PUB00004691], [cite:PUB00002669]]. IDH is either dependent on NAD<sup>+</sup> ([ec:1.1.1.41]) or on NADP<sup>+</sup> ([ec:1.1.1.42]). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD<sup>+</sup>-dependent, the other NADP<sup>+</sup>-dependent), while the third one (also NADP<sup>+</sup>-dependent) is cytoplasmic. In Escherichia coli, the activity of a NADP<sup>+</sup>-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.</p> <p>IMDH ([ec:1.1.1.85]) catalyses the third step in the biosynthesis of leucine in bacteria and fungi, the oxidative decarboxylation of 3-isopropylmalate into 2-oxo-4-methylvalerate [[cite:PUB00003276], [cite:PUB00005036]].</p> <p>This entry represents a structural domain found in all types of isocitrate dehydrogenase, and in isopropylmalate dehydrogenase and tartrate dehydrogenase. The crystal structure of Escherichia coli isopropylmalate dehydrogenase has been described [[cite:PUB00022856]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

Associated Lotus transcripts 24

Transcript Name Description Predicted domains Domain count
PREDICTED: isocitrate dehydrogenase [NADP] gi|356513947|ref|XP_003525669.1| 8
PREDICTED: isocitrate dehydrogenase [NAD] gi|356559222|ref|XP_003547899.1| 10
PREDICTED: isocitrate dehydrogenase [NADP] gi|502096593|ref|XP_004490788.1| 11
PREDICTED: isocitrate dehydrogenase [NADP] gi|356513947|ref|XP_003525669.1| 11
Isocitrate dehydrogenase [Medicago truncatula] gi|357517753|ref|XP_003629165.1| 8
PREDICTED: isocitrate dehydrogenase [NAD] gi|502161678|ref|XP_004512246.1| 8
PREDICTED: 3-isopropylmalate dehydrogenase, chloroplastic-like [Cicer arietinum] gi|502080646|ref|XP_004486631.1| 13
NADP-dependent isocitrate dehydrogenase [Glycine max] gi|351721946|ref|NP_001236203.1| 11
PREDICTED: isocitrate dehydrogenase [NAD] gi|502132922|ref|XP_004501584.1| 9
PREDICTED: isocitrate dehydrogenase [NAD] gi|502132925|ref|XP_004501585.1| 9
Isocitrate dehydrogenase [NADP]; TAIR: AT1G65930.1 cytosolic NADP+-dependent isocitrate dehydrogenase; Swiss-Prot: sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0R0GQK7|A0A0R0GQK7_SOYBN Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi1g1v0219400 12
Isocitrate dehydrogenase [NADP]; TAIR: AT1G65930.1 cytosolic NADP+-dependent isocitrate dehydrogenase; Swiss-Prot: sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|C6T857|C6T857_SOYBN Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi1g1v0219400 12
Isocitrate dehydrogenase [NADP]; TAIR: AT1G65930.1 cytosolic NADP+-dependent isocitrate dehydrogenase; Swiss-Prot: sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|C6T857|C6T857_SOYBN Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi1g1v0219400 12
Isocitrate dehydrogenase, putative; TAIR: AT4G35260.1 isocitrate dehydrogenase 1; Swiss-Prot: sp|Q8LFC0|IDH1_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; TrEMBL-Plants: tr|I1LI93|I1LI93_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0356600 9
3-isopropylmalate dehydrogenase; TAIR: AT4G35260.1 isocitrate dehydrogenase 1; Swiss-Prot: sp|Q8LFC0|IDH1_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; TrEMBL-Plants: tr|A0A0R0HDU0|A0A0R0HDU0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0356600 9
3-isopropylmalate dehydrogenase; TAIR: AT1G80560.1 isopropylmalate dehydrogenase 2; Swiss-Prot: sp|P29102|LEU3_BRANA 3-isopropylmalate dehydrogenase, chloroplastic; TrEMBL-Plants: tr|A0A151SPV9|A0A151SPV9_CAJCA 3-isopropylmalate dehydrogenase; Found in the gene: LotjaGi3g1v0006000 12
Isocitrate dehydrogenase [NADP]; TAIR: AT1G54340.1 isocitrate dehydrogenase; Swiss-Prot: sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0B2QN79|A0A0B2QN79_GLYSO Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi3g1v0130600 12
Isocitrate dehydrogenase [NADP]; TAIR: AT1G54340.1 isocitrate dehydrogenase; Swiss-Prot: sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0R0IMT3|A0A0R0IMT3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0130600 12
Isocitrate dehydrogenase [NADP]; TAIR: AT1G54340.1 isocitrate dehydrogenase; Swiss-Prot: sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0R0IMT3|A0A0R0IMT3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0130600 12
Isocitrate dehydrogenase [NADP]; TAIR: AT1G54340.1 isocitrate dehydrogenase; Swiss-Prot: sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP]; TrEMBL-Plants: tr|A0A0B2QN79|A0A0B2QN79_GLYSO Isocitrate dehydrogenase [NADP]; Found in the gene: LotjaGi3g1v0130600 12
3-isopropylmalate dehydrogenase; TAIR: AT4G35260.1 isocitrate dehydrogenase 1; Swiss-Prot: sp|Q8LFC0|IDH1_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; TrEMBL-Plants: tr|G7L9H2|G7L9H2_MEDTR NAD-dependent isocitrate dehydrogenase; Found in the gene: LotjaGi4g1v0137200 9
3-isopropylmalate dehydrogenase; TAIR: AT4G35260.1 isocitrate dehydrogenase 1; Swiss-Prot: sp|Q8LFC0|IDH1_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; TrEMBL-Plants: tr|I1MMY0|I1MMY0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0137200 9
Isopropylmalate dehydrogenase; TAIR: AT5G03290.1 isocitrate dehydrogenase V; Swiss-Prot: sp|Q945K7|IDH5_ARATH Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial; TrEMBL-Plants: tr|I3SWL7|I3SWL7_LOTJA Isocitrate dehydrogenase [NAD] subunit, mitochondrial; Found in the gene: LotjaGi5g1v0080100 11
Isopropylmalate dehydrogenase; TAIR: AT5G03290.1 isocitrate dehydrogenase V; Swiss-Prot: sp|Q945K7|IDH5_ARATH Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial; TrEMBL-Plants: tr|I3SPT9|I3SPT9_LOTJA Isocitrate dehydrogenase [NAD] subunit, mitochondrial; Found in the gene: LotjaGi5g1v0080100 9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF53659 SUPERFAMILY 1 4.17