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IPR004855 is a Transcription factor IIA, alpha/beta subunit.
<p>Transcription factor IIA (TFIIA) is one of several factors that form part of a transcription pre-initiation complex along with RNA polymerase II, the TATA-box-binding protein (TBP) and TBP-associated factors, on the TATA-box sequence upstream of the initiation start site. After initiation, some components of the pre-initiation complex (including TFIIA) remain attached and re-initiate a subsequent round of transcription. TFIIA binds to TBP to stabilise TBP binding to the TATA element. TFIIA also inhibits the cytokine HMGB1 (high mobility group 1 protein) binding to TBP [[cite:PUB00013248]], and can dissociate HMGB1 already bound to TBP/TATA-box.</p> <p>Human and Drosophila TFIIA have three subunits: two large subunits, LN/alpha and LC/beta, derived from the same gene, and a small subunit, S/gamma. Yeast TFIIA has two subunits: a large TOA1 subunit that shows sequence similarity to the N-terminal of LN/alpha and the C-terminal of LC/beta, and a small subunit, TOA2 that is highly homologous with S/gamma. The conserved regions of the large and small subunits of TFIIA combine to form two domains: a four-helix bundle (helical domain) composed of two helices from each of the N-terminal regions of TOA1 and TOA2 in yeast; and a β-barrel (β-barrel domain) composed of β-sheets from the C-terminal regions of TOA1 and TOA2 [[cite:PUB00013320]].</p> <p>This entry represents the precursor that yields both the alpha and beta subunits of TFIIA. The TFIIA heterotrimer is an essential general transcription initiation factor for the expression of genes transcribed by RNA polymerase II [[cite:PUB00007709]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Transcription factor TFIIA complex | A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). | ||
| Biological process | Transcription initiation from RNA polymerase II promoter | Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: transcription initiation factor IIA large subunit-like [Cicer arietinum] gi|502081823|ref|XP_004486980.1| | 14 | ||
| – | PREDICTED: transcription initiation factor IIA large subunit-like [Cicer arietinum] gi|502081823|ref|XP_004486980.1| | 14 | ||
| – | Transcription initiation factor IIA large subunit; TAIR: AT1G07470.1 Transcription factor IIA, alpha/beta subunit; Swiss-Prot: sp|Q9USU9|TOA1_SCHPO Transcription initiation factor IIA large subunit; TrEMBL-Plants: tr|A0A0B2RCP3|A0A0B2RCP3_GLYSO Transcription initiation factor IIA large subunit; Found in the gene: LotjaGi3g1v0286400 | 12 | ||
| – | Transcription initiation factor IIA large subunit; TAIR: AT1G07470.1 Transcription factor IIA, alpha/beta subunit; Swiss-Prot: sp|Q9USU9|TOA1_SCHPO Transcription initiation factor IIA large subunit; TrEMBL-Plants: tr|A0A0B2RCP3|A0A0B2RCP3_GLYSO Transcription initiation factor IIA large subunit; Found in the gene: LotjaGi3g1v0286400 | 12 | ||
| – | Transcription initiation factor IIA large subunit; TAIR: AT1G07480.1 Transcription factor IIA, alpha/beta subunit; Swiss-Prot: sp|Q9USU9|TOA1_SCHPO Transcription initiation factor IIA large subunit; TrEMBL-Plants: tr|V7BZ67|V7BZ67_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0490400 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |