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IPR005662 is a GTPase Era.
<p>Era is an essential G-protein in Escherichia coli identified originally as a homologue protein to Ras (E. coli Ras-like protein), which contains a N-terminal GTPase domain followed by an RNA-binding KH domain, that plays a role in ribosome biogenesis. It binds to GTP/GDP and has GTPase activity. It specifically bind to 16S rRNA and serves as a chaperone for processing and maturation of 16S rRNA. GTP binding is required for RNA recognition, which in turn, stimulates the GTP-hydrolyzing activity. ERA is also a checkpoint for assembly of the 30S ribosomal subunit [[cite:PUB00007879], [cite:PUB00055805]]. ERAL1, the homologue in humans, is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. It binds the 12S mitochondrial rRNA to a 33 nucleotide section delineating the 3' terminal stem-loop region [[cite:PUB00150959], [cite:PUB00150960]]. Mutations in this protein leads to Perrault syndrome, a rare recessive disorder characterised by ovarian dysgenesis and sensorineural deafness [[cite:PUB00150958]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: GTPase Era-like [Glycine max] gi|356502167|ref|XP_003519892.1| | 23 | ||
| – | GTPase Era; TAIR: AT1G30960.1 GTP-binding family protein; Swiss-Prot: sp|O82626|ERG_ANTMA GTP-binding protein ERG; TrEMBL-Plants: tr|G7KDM7|G7KDM7_MEDTR GTP-binding ERG-like protein; Found in the gene: LotjaGi2g1v0003800 | 26 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|V7CCY5|V7CCY5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 23 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|V7CCY5|V7CCY5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 28 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|A0A0S3R4P9|A0A0S3R4P9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 22 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|A0A0S3R4P9|A0A0S3R4P9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 22 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|A0A0S3R4P9|A0A0S3R4P9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 20 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B0TAF1|ERA_HELMI GTPase Era; TrEMBL-Plants: tr|A0A0L9TNW9|A0A0L9TNW9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04163 | CDD | 1 | 12.50 |