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IPR004044 is a K Homology domain, type 2.
<p>The K homology (KH) domain was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. It is a domain of around 70 amino acids that is present in a wide variety of quite diverse nucleic acid-binding proteins [[cite:PUB00005188]]. It has been shown to bind RNA [[cite:PUB00005961], [cite:PUB00005962]]. Like many other RNA-binding motifs, KH motifs are found in one or multiple copies (14 copies in chicken vigilin) and, at least for hnRNP K (three copies) and FMR-1 (two copies), each motif is necessary for<i>in vitro</i>RNA binding activity, suggesting that they may function cooperatively or, in the case of single KH motif proteins (for example, Mer1p), independently [[cite:PUB00005188]].</p> <p>According to structural analyses [[cite:PUB00005961], [cite:PUB00005962], [cite:PUB00007305]], the KH domain can be separated in two groups. The first group or type-1 contain a β-α-α-β-β-α structure, whereas in the type-2 the two last β-sheets are located in the N-terminal part of the domain (α-β-β-α-α-β). Sequence similarity between these two folds are limited to a short region (VIGXXGXXI) in the RNA binding motif. This motif is located between helice 1 and 2 in type-1 and between helice 2 and 3 in type-2. Proteins known to contain a type-2 KH domain include eukaryotic and prokaryotic S3 family of ribosomal proteins, and the prokaryotic GTP-binding protein era.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 40S ribosomal protein S3-1-like [Cicer arietinum] gi|502131540|ref|XP_004501017.1| | 10 | ||
| – | PREDICTED: 40S ribosomal protein S3-3-like [Cicer arietinum] gi|502122563|ref|XP_004497806.1| | 18 | ||
| – | PREDICTED: GTPase Era-like [Glycine max] gi|356502167|ref|XP_003519892.1| | 23 | ||
| – | 30S ribosomal protein S3; TAIR: AT5G35530.1 Ribosomal protein S3 family protein; Swiss-Prot: sp|Q9FJA6|RS33_ARATH 40S ribosomal protein S3-3; TrEMBL-Plants: tr|I3S6J8|I3S6J8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0556400 | 19 | ||
| – | GTPase Era; TAIR: AT1G30960.1 GTP-binding family protein; Swiss-Prot: sp|O82626|ERG_ANTMA GTP-binding protein ERG; TrEMBL-Plants: tr|G7KDM7|G7KDM7_MEDTR GTP-binding ERG-like protein; Found in the gene: LotjaGi2g1v0003800 | 26 | ||
| – | 30S ribosomal protein S3; TAIR: AT5G35530.1 Ribosomal protein S3 family protein; Swiss-Prot: sp|Q9FJA6|RS33_ARATH 40S ribosomal protein S3-3; TrEMBL-Plants: tr|I3SJI7|I3SJI7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0314100 | 19 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|V7CCY5|V7CCY5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 23 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|V7CCY5|V7CCY5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 28 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|A0A0S3R4P9|A0A0S3R4P9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 22 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|A0A0S3R4P9|A0A0S3R4P9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 22 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B2V2K0|ERA_CLOBA GTPase Era; TrEMBL-Plants: tr|A0A0S3R4P9|A0A0S3R4P9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 20 | ||
| – | GTPase Era; TAIR: AT5G66470.1 GTP-binding protein Era-like protein; Swiss-Prot: sp|B0TAF1|ERA_HELMI GTPase Era; TrEMBL-Plants: tr|A0A0L9TNW9|A0A0L9TNW9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0120100 | 23 | ||
| – | 30S ribosomal protein S3; TAIR: AT5G35530.1 Ribosomal protein S3 family protein; Swiss-Prot: sp|Q9FJA6|RS33_ARATH 40S ribosomal protein S3-3; TrEMBL-Plants: tr|A0A151SP15|A0A151SP15_CAJCA 40S ribosomal protein S3-3; Found in the gene: LotjaGi6g1v0008800 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02413 | CDD | 1 | 7.69 |