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IPR006466 is a MiaB-like tRNA modifying enzyme, archaea/eukaryota.
<p>This clade of sequences is closely related to MiaB, a modifier of isopentenylated adenosine-37 of certain eukaryotic and bacterial tRNAs (see [interpro:IPR006463]). Sequence alignments suggest that this family of sequences perform the same chemical transformation as MiaB, perhaps on a different (or differently modified) tRNA base substrate. This clade represents a subfamily that spans the archaea and eukaryotes. The only archaeal miaB-like genes are in this group of sequences [[cite:PUB00009727], [cite:PUB00009728], [cite:PUB00009729]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | N6-threonylcarbomyladenosine methylthiotransferase activity | Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A). | ||
| Biological process | TRNA methylthiolation | The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: CDKAL1-like protein-like [Glycine max] gi|356542899|ref|XP_003539902.1| | 29 | ||
| – | TRNA-2-methylthio-N(6)-dimethylallyladenosine synthase; TAIR: AT1G72090.1 Methylthiotransferase; Swiss-Prot: sp|Q6P4Y0|CDKAL_XENTR Threonylcarbamoyladenosine tRNA methylthiotransferase; TrEMBL-Plants: tr|I1LNN6|I1LNN6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0556600 | 29 | ||
| – | TRNA-2-methylthio-N(6)-dimethylallyladenosine synthase; TAIR: AT1G72090.1 Methylthiotransferase; Swiss-Prot: sp|Q6NS26|CDKAL_XENLA Threonylcarbamoyladenosine tRNA methylthiotransferase; TrEMBL-Plants: tr|I1LNN6|I1LNN6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0556600 | 29 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01335 | CDD | 1 | 33.33 |