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IPR006703 is a AIG1-type guanine nucleotide-binding (G) domain.
<p>This entry represents the AIG1-type G domain.</p> <p>The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state and an active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides.</p> <p>The TRAFAC (translation factor related) class AIG1/Toc34/Toc159-like paraseptin GTPase family contains the following subfamilies [[cite:PUB00013952]]:</p> <ul> <li>The GTPases of immunity-associated protein (GIMAP)/immune-associated nucleotide-binding protein (IAN) subfamily is conserved among vertebrates and angiosperm plants and has been postulated to regulate apoptosis, particularly in context with diseases such as cancer, diabetes, and infections. The function of GIMAP/IAN GTPases has been linked to self defense in plants and to the development of T cells in vertebrates [[cite:PUB00072526], [cite:PUB00066172]].</li> <li>Plant-specific Toc (translocon at the outer envelope membrane of chloroplasts) proteins. Toc proteins function as integral components of the chloroplast protein import machinery. The Toc translocon contains the two membrane-bound GTPases Toc33/34 and Toc 159, which expose their G domains to the cytosol and recognise and then deliver precursor proteins through the translocation pore Toc75 [[cite:PUB00047782], [cite:PUB00050571]].</li> </ul> <p>The GIMAP/IAN GTPases contain a avrRpt2 induced gene 1 (AIG1)-type G domain that exhibits the five motifs G1-G5 characteristic for GTP/GDP-binding proteins. In addition, the AIG-type G domain contains a unique, highly conserved, hydrophobic motif between G3 and G4. It has a divergent version of the guanine recognition motif (G4) at the end of the core strand 5 and an additional helix alpha6 at the C terminus. The AIG1-type G domain contains a central β-sheet sandwiched by two layers of α-helices.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: translocase of chloroplast 34-like [Glycine max] gi|356571841|ref|XP_003554080.1| | 11 | ||
– | PREDICTED: protein AIG1-like [Glycine max] gi|356526433|ref|XP_003531822.1| | 10 | ||
– | PREDICTED: translocase of chloroplast 132, chloroplastic-like [Glycine max] gi|356541023|ref|XP_003538983.1| | 15 | ||
– | 15 | |||
– | 15 | |||
– | PREDICTED: translocase of chloroplast 90, chloroplastic-like [Glycine max] gi|356546132|ref|XP_003541485.1| | 17 | ||
– | Chloroplast protein import component Toc159 [Pisum sativum] gi|8489806|gb|AAF75761.1|AF262939_1 | 15 | ||
– | Translocase of chloroplast; TAIR: AT5G05000.1 translocon at the outer envelope membrane of chloroplasts 34; Swiss-Prot: sp|Q41009|TOC34_PEA Translocase of chloroplast 34; TrEMBL-Plants: tr|K7MY05|K7MY05_SOYBN Translocase of chloroplast; Found in the gene: LotjaGi1g1v0653800 | 12 | ||
– | Translocase of chloroplast; TAIR: AT5G05000.1 translocon at the outer envelope membrane of chloroplasts 34; Swiss-Prot: sp|Q41009|TOC34_PEA Translocase of chloroplast 34; TrEMBL-Plants: tr|K7MY05|K7MY05_SOYBN Translocase of chloroplast; Found in the gene: LotjaGi1g1v0653800 | 12 | ||
– | Translocase of chloroplast; TAIR: AT5G05000.1 translocon at the outer envelope membrane of chloroplasts 34; Swiss-Prot: sp|Q41009|TOC34_PEA Translocase of chloroplast 34; TrEMBL-Plants: tr|K7MY05|K7MY05_SOYBN Translocase of chloroplast; Found in the gene: LotjaGi1g1v0653800 | 12 | ||
– | Protein AIG1; TAIR: AT1G33970.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|F4HT21|IAN9_ARATH Immune-associated nucleotide-binding protein 9; TrEMBL-Plants: tr|I3SDB7|I3SDB7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0416800 | 10 | ||
– | TRNA modification GTPase MnmE; TAIR: AT1G33970.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|F4HT21|IAN9_ARATH Immune-associated nucleotide-binding protein 9; TrEMBL-Plants: tr|I3SDB7|I3SDB7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0417000 | 10 | ||
– | Translocase of chloroplast; TAIR: AT2G16640.1 multimeric translocon complex in the outer envelope membrane 132; Swiss-Prot: sp|Q9SLF3|TC132_ARATH Translocase of chloroplast 132, chloroplastic; TrEMBL-Plants: tr|I1LIY4|I1LIY4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0523700 | 15 | ||
– | Translocase of chloroplast 90, chloroplastic; TAIR: AT5G20300.1 Avirulence induced gene (AIG1) family protein; Swiss-Prot: sp|Q6S5G3|TOC90_ARATH Translocase of chloroplast 90, chloroplastic; TrEMBL-Plants: tr|I1LZT2|I1LZT2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0278900 | 16 | ||
– | TRNA modification GTPase MnmE; TAIR: AT4G02510.1 translocon at the outer envelope membrane of chloroplasts 159; Swiss-Prot: sp|O81283|TC159_ARATH Translocase of chloroplast 159, chloroplastic; TrEMBL-Plants: tr|G7JLH6|G7JLH6_MEDTR 50S ribosome-binding GTPase; Found in the gene: LotjaGi4g1v0341400 | 9 | ||
– | Translocase of chloroplast 159, chloroplastic; TAIR: AT4G02510.1 translocon at the outer envelope membrane of chloroplasts 159; Swiss-Prot: sp|O81283|TC159_ARATH Translocase of chloroplast 159, chloroplastic; TrEMBL-Plants: tr|K7KQN4|K7KQN4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0385900 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 6.25 |