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IPR010995 is a DNA repair Rad51/transcription factor NusA, alpha-helical.
<p>This superfamily represents an α-helical bundle domain, which has a SAM domain-like fold. This compact domain consists of a 4-5 helical bundle of two orthogonally packed α-hairpins, and contains one classic and one pseudo HhH (helix-hairpin-helix) motif. This domain is found at N-terminal of the DNA repair protein Rad51, at the C-terminal of the transcription elongation protein NusA, and at the C-terminal of the hypothetical protein AF1548.</p> <p>Human Rad51 protein is a homologue of Escherichia coli RecA protein, and functions in DNA repair and recombination [[cite:PUB00014057]]. In higher eukaryotes, Rad51 protein is essential for cell viability. The N-terminal region of Rad51 is highly conserved among eukaryotic Rad51 proteins but is absent from RecA, suggesting a Rad51-specific function for this region. The-terminal domain is involved in interactions with DNA and proteins; DNA binding may be regulated via phosphorylation within the N-terminal domain.</p> <p>NusA (N utilisation substance A) from E. coli is an essential transcription factor that associates with the RNA polymerase (RNAP) core enzyme, where it modulates transcriptional pausing, termination and anti-termination [[cite:PUB00035974]]. The C-terminal of NusA consists of two repeat units, and is responsible for the interaction of NisA with the C-terminal of RNAP, and with its interaction with protein N from phage lambda during anti-termination [[cite:PUB00031711]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nucleotide binding | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Meiotic recombination protein DMC1 homolog [Glycine max] gi|351726994|ref|NP_001238425.1| | 20 | ||
| – | PREDICTED: DNA repair protein RAD51 homolog 3-like isoform X1 [Cicer arietinum] gi|502146616|ref|XP_004506531.1| | 16 | ||
| – | PREDICTED: DNA repair protein RAD51 homolog 3-like isoform X1 [Cicer arietinum] gi|502146616|ref|XP_004506531.1| | 16 | ||
| – | PREDICTED: DNA repair protein RAD51 homolog 1-like [Cicer arietinum] gi|502150634|ref|XP_004508049.1| | 24 | ||
| – | PREDICTED: meiotic recombination protein DMC1 homolog [Cicer arietinum] gi|502119553|ref|XP_004496658.1| | 16 | ||
| – | DNA repair family protein; TAIR: AT2G45280.1 RAS associated with diabetes protein 51C; Swiss-Prot: sp|Q8GXF0|RA51C_ARATH DNA repair protein RAD51 homolog 3; TrEMBL-Plants: tr|A0A0B2RTD8|A0A0B2RTD8_GLYSO DNA repair protein RAD51 like 3; Found in the gene: LotjaGi3g1v0435300 | 15 | ||
| – | DNA repair family protein; TAIR: AT2G45280.1 RAS associated with diabetes protein 51C; Swiss-Prot: sp|Q8GXF0|RA51C_ARATH DNA repair protein RAD51 homolog 3; TrEMBL-Plants: tr|A0A0B2RTD8|A0A0B2RTD8_GLYSO DNA repair protein RAD51 like 3; Found in the gene: LotjaGi3g1v0435300 | 15 | ||
| – | DNA repair family protein; TAIR: AT2G45280.1 RAS associated with diabetes protein 51C; Swiss-Prot: sp|Q8GXF0|RA51C_ARATH DNA repair protein RAD51 homolog 3; TrEMBL-Plants: tr|A0A0R0KE22|A0A0R0KE22_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0435300 | 15 | ||
| – | DNA repair protein RAD51 like 1; TAIR: AT5G20850.1 RAS associated with diabetes protein 51; Swiss-Prot: sp|P94102|RAD51_ARATH DNA repair protein RAD51 homolog 1; TrEMBL-Plants: tr|A0A151SSM0|A0A151SSM0_CAJCA DNA repair protein RAD51 isogeny 1; Found in the gene: LotjaGi4g1v0319500 | 24 | ||
| – | Disrupted meiotic cDNA 1 protein; TAIR: AT3G22880.1 DNA repair (Rad51) family protein; Swiss-Prot: sp|Q96449|DMC1_SOYBN Meiotic recombination protein DMC1 homolog; TrEMBL-Plants: tr|A0A0R0HYK0|A0A0R0HYK0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0309600 | 22 | ||
| – | Disrupted meiotic cDNA 1 protein; TAIR: AT3G22880.2 DNA repair (Rad51) family protein; Swiss-Prot: sp|Q96449|DMC1_SOYBN Meiotic recombination protein DMC1 homolog; TrEMBL-Plants: tr|K7LL69|K7LL69_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0309600 | 22 | ||
| – | Disrupted meiotic cDNA 1 protein; TAIR: AT3G22880.2 DNA repair (Rad51) family protein; Swiss-Prot: sp|Q96449|DMC1_SOYBN Meiotic recombination protein DMC1 homolog; TrEMBL-Plants: tr|A0A151U6N0|A0A151U6N0_CAJCA Meiotic recombination protein DMC1 isogeny; Found in the gene: LotjaGi5g1v0309600 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01123 | CDD | 1 | 8.33 |