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IPR011764 is a Biotin carboxylation domain.
<p>Biotin-dependent carboxylase enzymes perform a two step reaction. Enzyme-bound biotin is first carboxylated by bicarbonated and ATP and the carboxyl group temporarily bound to biotin is subsequently transferred to an acceptor substrate such as pyruvate or acetyl-CoA. The first step is mediated by the BC domain common to all biotin-dependent carboxylases [[cite:PUB00015350]]. The BC domain can be divided in three subdomains (N-terminal, central and C-terminal). The N-terminal region provides part of the active site; the central region corresponds to the ATP-grasp domain, which is common to many ATP-dependent enzymes involved in macromolecular synthesis [[cite:PUB00015348]]. The ATP-grasp module directly binds the ATP molecule. The C-terminal subdomain is involved in dimer formation.</p> <p>Several structure of the BC domain have been solved [[cite:PUB00015349], [cite:PUB00014226]]. The central module is splayed significantly away from the main body of the domain and is able to rotate of approximately 45 degree upon nucleotide binding thereby closing off the active site pocket [[cite:PUB00014226]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: biotin carboxylase 1, chloroplastic-like [Cicer arietinum] gi|502138858|ref|XP_004503555.1| | 26 | ||
| – | PREDICTED: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial-like isoform X2 [Cicer arietinum] gi|502115337|ref|XP_004495179.1| | 33 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|A0A0R0K6S7|A0A0R0K6S7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 46 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|A0A0R0K6S7|A0A0R0K6S7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 46 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|I1JVH6|I1JVH6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 46 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|A0A0R0K6S7|A0A0R0K6S7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 46 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|A0A0R0K6S7|A0A0R0K6S7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 32 | ||
| – | Biotin carboxylase; TAIR: AT5G35360.1 acetyl Co-enzyme a carboxylase biotin carboxylase subunit; Swiss-Prot: sp|B9HBA8|ACCC1_POPTR Biotin carboxylase 1, chloroplastic; TrEMBL-Plants: tr|O23960|O23960_SOYBN Acetyl-CoA carboxylase; Found in the gene: LotjaGi4g1v0439600 | 23 | ||
| – | Biotin carboxylase; TAIR: AT5G35360.1 acetyl Co-enzyme a carboxylase biotin carboxylase subunit; Swiss-Prot: sp|B9HBA8|ACCC1_POPTR Biotin carboxylase 1, chloroplastic; TrEMBL-Plants: tr|O23960|O23960_SOYBN Acetyl-CoA carboxylase; Found in the gene: LotjaGi4g1v0439600 | 23 | ||
| – | Acetyl-CoA carboxylase, putative; TAIR: AT1G03090.2 methylcrotonyl-CoA carboxylase alpha chain; Swiss-Prot: sp|Q42777|MCCA_SOYBN Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; TrEMBL-Plants: tr|A0A151QXF8|A0A151QXF8_CAJCA Uncharacterized protein; Found in the gene: LotjaGi5g1v0170200 | 30 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06850 | CDD | 1 | 10.00 |