Description

IPR012887 is a GDP-fucose pyrophosphorylase domain.

<p>This entry represents the fucose pyrophosphorylase domain found at the N-terminal of the bifunctional L-Fucokinase/GDP-Fucose Pyrophosphorylase (FKP) enzymes such as FKGP from Arabidopsis and L-fucose kinase from animals [[cite:PUB00155376], [cite:PUB00155377]]. In fucose-1-phosphate guanylyltransferase from human, this is the main domain of the protein, which catalyses the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate and functions as a salvage pathway to reutilise L-fucose arising from the turnover of glycoproteins and glycolipids [[cite:PUB00015901], [cite:PUB00016201]]. In the salvage pathway, cells use fucose from the extracellular or lysosomal sources to synthesise GDP-fucose. First, the fucokinase catalyses the formation of fucose-1-phosphate from fucose, with ATP consumption and then, the GDP-fucose pyrophosphorylase (GFPP) uses fucose-1-phosphate and GTP to synthesise GDP-fucose. I some members, the two independent catalytic reactions in the salvage pathway can be accomplished by a single enzyme, the fucokinase/GDP-fucose pyrophosphorylase (FKP). The structure of the bifunctional enzyme from Bacteroides fragilis have been determined [[cite:PUB00155378]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: