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IPR013048 is a Meiotic recombination, Spo11.
<p>Spo11 is a meiosis-specific protein that is responsible for the initiation of recombination during the early stages of meiosis through the formation of DNA double-strand breaks (DSBs) by a type II DNA topoisomerase-like activity [[cite:PUB00007203], [cite:PUB00083725]]. These DSBs initiate homologous recombination, which is required for chromosomal segregation and generation of genetic diversity during meiosis. Spo11 acts in conjunction with several other proteins, including Rec102 in yeast, to bring about meiotic recombination [[cite:PUB00020805]]. Mouse and human homologues of Spo11 have been cloned and characterised. The proteins are 82% identical and share ~25% identity with other family members. Mouse Spo11 has been localised to chromosome 2H4, and human SPO11 to chromosome 20q13.2-q13.3, a region amplified in some breast and ovarian tumours [[cite:PUB00007203]].</p> <p>Similarity between SPO11 and archaebacterial TOP6A proteins points to evolutionary specialisation of a DNA-cleavage function for meiotic recombination [[cite:PUB00007204]]. Note that the yeast SPO11 protein shares far less similarity to other SPO11 proteins than the human and mouse homologues do to each other.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: meiotic recombination protein SPO11-1-like [Glycine max] gi|356499439|ref|XP_003518548.1| | 9 | ||
| – | RHL2 [Zea mays] gi|195647934|gb|ACG43435.1| | 8 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT3G13170.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9M4A2|SPO11_ARATH Meiotic recombination protein SPO11-1; TrEMBL-Plants: tr|G7K4J7|G7K4J7_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi1g1v0016700 | 11 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT3G13170.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9M4A2|SPO11_ARATH Meiotic recombination protein SPO11-1; TrEMBL-Plants: tr|G7K4J7|G7K4J7_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi1g1v0016700 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00223 | CDD | 1 | 25.00 |