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IPR036078 is a Spo11/DNA topoisomerase VI subunit A superfamily.
<p>This entry represents Spo11, a meiotic recombination protein found in eukaryotes, and subunit A of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea [[cite:PUB00007202], [cite:PUB00020804], [cite:PUB00083725], [cite:PUB00075470]]. These two types of proteins share structural homology.</p> <p>DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks. They can be divided into two classes: type I enzymes ([ec:5.6.2.1], topoisomerases I, III and V) break single-strand DNA, and type II enzymes ([ec:5.6.2.2], topoisomerases II, IV and VI) break double-strand DNA [[cite:PUB00020793]]. Topoisomerase VI is a type IIB enzymes that assembles as a heterotetramer, consisting of two A subunits required for DNA cleavage and two B subunits required for ATP hydrolysis. The B subunit is structurally similar to the ATPase domain of type IIA topoisomerases, but the A subunit is distinct, and instead shares homology with the Spo11 protein.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Biological process | DNA catabolic process, endonucleolytic | The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. | ||
Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
Cellular component | Chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | DNA topoisomerase 6 subunit A; TAIR: AT3G13170.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9M4A2|SPO11_ARATH Meiotic recombination protein SPO11-1; TrEMBL-Plants: tr|G7K4J7|G7K4J7_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi1g1v0016700 | 11 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT3G13170.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9M4A2|SPO11_ARATH Meiotic recombination protein SPO11-1; TrEMBL-Plants: tr|G7K4J7|G7K4J7_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi1g1v0016700 | 11 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|A2XFC1|TOP6A_ORYSI DNA topoisomerase 6 subunit A3; TrEMBL-Plants: tr|A0A061R4D2|A0A061R4D2_9CHLO DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi2g1v0088900_LC | 9 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9LZ03|TOP6A_ARATH DNA topoisomerase 6 subunit A; TrEMBL-Plants: tr|A0A061R4D2|A0A061R4D2_9CHLO DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi2g1v0088900_LC | 9 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|A2XFC1|TOP6A_ORYSI DNA topoisomerase 6 subunit A3; TrEMBL-Plants: tr|A0A061R4D2|A0A061R4D2_9CHLO DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi2g1v0088900_LC | 7 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|I1LGD2|I1LGD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|G7KC02|G7KC02_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.2 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|I1LGD2|I1LGD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 11 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|I1LGD2|I1LGD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|K7LMM4|K7LMM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 9 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|K7LMM4|K7LMM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9LZ03|TOP6A_ARATH DNA topoisomerase 6 subunit A; TrEMBL-Plants: tr|A0A068F783|A0A068F783_LOTJA DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi5g1v0072800 | 17 | ||
– | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|A2XFC1|TOP6A_ORYSI DNA topoisomerase 6 subunit A3; TrEMBL-Plants: tr|I1H6P7|I1H6P7_BRADI DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi6g1v0346800 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd00223 | CDD | 1 | 7.69 |