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IPR034136 is a Topoisomerase 6 subunit A/Spo11, TOPRIM domain.
<p>This topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain is found in the type II topoisomerase VIA and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VIA (TopoVIA) [[cite:PUB00082741]] and Saccharomyces cerevisiae meiotic recombination factor Spo11 [[cite:PUB00083109]]. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. TopoVI enzymes are heterotetramers found in archaea and plants [[cite:PUB00020804], [cite:PUB00080580]]. Spo11 plays a role in generating the double strand breaks that initiate homologous recombination during meiosis [[cite:PUB00082743], [cite:PUB00082742]]. S. shibatae TopoVI relaxes both positive and negative supercoils, and in addition has a strong decatenase activity [[cite:PUB00007202]].</p> <p>The TOPRIM domain has two conserved motifs, one of which centres at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases, the conserved glutamate is believed to act as a general base in strand joining, and as a general acid in strand cleavage [[cite:PUB00004485]]. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA topoisomerase 6 subunit A; TAIR: AT3G13170.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9M4A2|SPO11_ARATH Meiotic recombination protein SPO11-1; TrEMBL-Plants: tr|G7K4J7|G7K4J7_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi1g1v0016700 | 11 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT3G13170.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9M4A2|SPO11_ARATH Meiotic recombination protein SPO11-1; TrEMBL-Plants: tr|G7K4J7|G7K4J7_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi1g1v0016700 | 11 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|I1LGD2|I1LGD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|G7KC02|G7KC02_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|I1LGD2|I1LGD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|K7LMM4|K7LMM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 9 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|K7LMM4|K7LMM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9LZ03|TOP6A_ARATH DNA topoisomerase 6 subunit A; TrEMBL-Plants: tr|A0A068F783|A0A068F783_LOTJA DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi5g1v0072800 | 17 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|A2XFC1|TOP6A_ORYSI DNA topoisomerase 6 subunit A3; TrEMBL-Plants: tr|I1H6P7|I1H6P7_BRADI DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi6g1v0346800 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00223 | CDD | 1 | 11.11 |