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IPR016157 is a Cullin, conserved site.
<p>Cullins are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). Cullins are found throughout eukaryotes. Humans express several cullins (Cul1, 2, 3, 4A, 4B, 5, 7 and 9), each forming part of a multi-subunit ubiquitin complex [[cite:PUB00103546], [cite:PUB00075111]]. Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) [[cite:PUB00000937]], play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as the APC2 subunit of the anaphase-promoting complex/cyclosome and the p53 cytoplasmic anchor PARC; both APC2 and PARC have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins [[cite:PUB00042618], [cite:PUB00010627], [cite:PUB00031678]].</p> <p>This entry represents a conserved site found in various cullin proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. | ||
| Cellular component | Cullin-RING ubiquitin ligase complex | Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. | ||
| Molecular function | Ubiquitin protein ligase binding | Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A0S3S3A0|A0A0S3S3A0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200 | 25 | ||
| – | Cullin; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
| – | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|V7BPK5|V7BPK5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200 | 25 | ||
| – | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
| – | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
| – | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF75632 | SUPERFAMILY | 1 | 16.67 |