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IPR016158 is a Cullin homology domain.
<p>Cullins are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). Cullins are found throughout eukaryotes. Humans express several cullins (Cul1, 2, 3, 4A, 4B, 5, 7 and 9), each forming part of a multi-subunit ubiquitin complex [[cite:PUB00103546], [cite:PUB00075111]]. Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) [[cite:PUB00000937]], play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as the APC2 subunit of the anaphase-promoting complex/cyclosome and the p53 cytoplasmic anchor PARC; both APC2 and PARC have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins [[cite:PUB00042618], [cite:PUB00010627], [cite:PUB00031678]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: cullin-1-like isoform 1 [Glycine max] gi|356563944|ref|XP_003550217.1| | 13 | ||
– | PREDICTED: anaphase-promoting complex subunit 2-like [Glycine max] gi|356537932|ref|XP_003537460.1| | 17 | ||
– | PREDICTED: anaphase-promoting complex subunit 2-like [Glycine max] gi|356537932|ref|XP_003537460.1| | 17 | ||
– | PREDICTED: anaphase-promoting complex subunit 2-like, partial [Cicer arietinum] gi|502183944|ref|XP_004517251.1| | 14 | ||
– | Anaphase-promoting complex subunit [Medicago truncatula] gi|357474931|ref|XP_003607751.1| | 10 | ||
– | PREDICTED: cullin-1-like [Cicer arietinum] gi|502112494|ref|XP_004494349.1| | 16 | ||
– | PREDICTED: cullin-3A-like [Glycine max] gi|356572514|ref|XP_003554413.1| | 18 | ||
– | PREDICTED: cullin-3A-like [Cicer arietinum] gi|502093740|ref|XP_004490037.1| | 15 | ||
– | PREDICTED: cullin-1-like [Glycine max] gi|356556122|ref|XP_003546376.1| | 16 | ||
– | PREDICTED: cullin-1-like isoform 1 [Glycine max] gi|356563944|ref|XP_003550217.1| | 18 | ||
– | PREDICTED: cullin-4-like [Glycine max] gi|356555528|ref|XP_003546083.1| | 21 | ||
– | Cullin 1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1NB34|I1NB34_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0767400 | 21 | ||
– | Cullin family protein; TAIR: AT1G69670.1 cullin 3B; Swiss-Prot: sp|Q9C9L0|CUL3B_ARATH Cullin-3B; TrEMBL-Plants: tr|A0A0L9VNM3|A0A0L9VNM3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0258300 | 20 | ||
– | Cullin, putative; TAIR: AT1G26830.1 cullin 3; Swiss-Prot: sp|Q9ZVH4|CUL3A_ARATH Cullin-3A; TrEMBL-Plants: tr|A0A0L9VNM3|A0A0L9VNM3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0258300 | 20 | ||
– | Cullin family protein; TAIR: AT1G26830.1 cullin 3; Swiss-Prot: sp|Q9ZVH4|CUL3A_ARATH Cullin-3A; TrEMBL-Plants: tr|I1KXS9|I1KXS9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0304900 | 20 | ||
– | Cullin, putative; TAIR: AT1G26830.1 cullin 3; Swiss-Prot: sp|Q9ZVH4|CUL3A_ARATH Cullin-3A; TrEMBL-Plants: tr|A0A1J7HV59|A0A1J7HV59_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0304900 | 20 | ||
– | Anaphase promoting complex subunit 2; TAIR: AT2G04660.1 anaphase-promoting complex/cyclosome 2; Swiss-Prot: sp|Q8H1U5|APC2_ARATH Anaphase-promoting complex subunit 2; TrEMBL-Plants: tr|G7JG99|G7JG99_MEDTR Anaphase promoting complex subunit 2; Found in the gene: LotjaGi4g1v0090400 | 21 | ||
– | Anaphase promoting complex subunit 2; TAIR: AT2G04660.1 anaphase-promoting complex/cyclosome 2; Swiss-Prot: sp|Q8H1U5|APC2_ARATH Anaphase-promoting complex subunit 2; TrEMBL-Plants: tr|G7JG99|G7JG99_MEDTR Anaphase promoting complex subunit 2; Found in the gene: LotjaGi4g1v0090400 | 21 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MRG8|I1MRG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0344300 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MRG8|I1MRG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0344300 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MRG8|I1MRG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0344300 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MRG8|I1MRG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0344300 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1L117|I1L117_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 21 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|A0A0B2STE7|A0A0B2STE7_GLYSO Cullin-1; Found in the gene: LotjaGi6g1v0248100 | 18 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|A0A0R0G189|A0A0R0G189_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 21 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1L117|I1L117_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 21 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1L117|I1L117_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 21 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A0S3S3A0|A0A0S3S3A0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200 | 25 | ||
– | Cullin; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|V7BPK5|V7BPK5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200 | 16 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|V7BPK5|V7BPK5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200 | 25 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
SSF75632 | SUPERFAMILY | 1 | 2.94 |