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IPR019559 is a Cullin protein, neddylation domain.
<p>This is the neddylation site of cullin proteins, which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae (Baker's yeast), and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue [[cite:PUB00044220]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: cullin-1-like [Cicer arietinum] gi|502112494|ref|XP_004494349.1| | 16 | ||
– | PREDICTED: cullin-3A-like [Glycine max] gi|356572514|ref|XP_003554413.1| | 18 | ||
– | PREDICTED: cullin-1-like [Glycine max] gi|356556122|ref|XP_003546376.1| | 16 | ||
– | PREDICTED: cullin-1-like isoform 1 [Glycine max] gi|356563944|ref|XP_003550217.1| | 18 | ||
– | PREDICTED: cullin-4-like [Glycine max] gi|356555528|ref|XP_003546083.1| | 21 | ||
– | Cullin 1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1NB34|I1NB34_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0767400 | 21 | ||
– | Cullin family protein; TAIR: AT1G69670.1 cullin 3B; Swiss-Prot: sp|Q9C9L0|CUL3B_ARATH Cullin-3B; TrEMBL-Plants: tr|A0A0L9VNM3|A0A0L9VNM3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0258300 | 20 | ||
– | Cullin, putative; TAIR: AT1G26830.1 cullin 3; Swiss-Prot: sp|Q9ZVH4|CUL3A_ARATH Cullin-3A; TrEMBL-Plants: tr|A0A0L9VNM3|A0A0L9VNM3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0258300 | 20 | ||
– | Cullin family protein; TAIR: AT1G26830.1 cullin 3; Swiss-Prot: sp|Q9ZVH4|CUL3A_ARATH Cullin-3A; TrEMBL-Plants: tr|I1KXS9|I1KXS9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0304900 | 20 | ||
– | Cullin, putative; TAIR: AT1G26830.1 cullin 3; Swiss-Prot: sp|Q9ZVH4|CUL3A_ARATH Cullin-3A; TrEMBL-Plants: tr|A0A1J7HV59|A0A1J7HV59_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0304900 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MRG8|I1MRG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0344300 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MRG8|I1MRG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0344300 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MRG8|I1MRG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0344300 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MRG8|I1MRG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0344300 | 20 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|A0A072USG4|A0A072USG4_MEDTR Cullin 3B; Found in the gene: LotjaGi4g1v0344300 | 10 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1L117|I1L117_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 21 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1MGR4|I1MGR4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 10 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|A0A0B2STE7|A0A0B2STE7_GLYSO Cullin-1; Found in the gene: LotjaGi6g1v0248100 | 18 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|A0A0R0G189|A0A0R0G189_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 21 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1L117|I1L117_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 21 | ||
– | Cullin-1; TAIR: AT4G02570.1 cullin 1; Swiss-Prot: sp|Q94AH6|CUL1_ARATH Cullin-1; TrEMBL-Plants: tr|I1L117|I1L117_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0248100 | 21 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A0S3S3A0|A0A0S3S3A0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200 | 25 | ||
– | Cullin; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|V7BPK5|V7BPK5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200 | 25 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 | ||
– | Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
SSF75632 | SUPERFAMILY | 1 | 3.70 |