Description

IPR016190 is a Translation initiation factor IF2/IF5, zinc-binding.

<p>The beta subunit of archaeal and eukaryotic translation initiation factor 2 (IF2beta) and the N-terminal domain of translation initiation factor 5 (IF5) show significant sequence homology [[cite:PUB00017012]]. Archaeal IF2beta contains two independent structural domains: an N-terminal mixed α/β core domain (topological similarity to the common core of ribosomal proteins L23 and L15e), and a C-terminal domain consisting of a zinc-binding C4 finger [[cite:PUB00017014]]. Archaeal IF2beta is a ribosome-dependent GTPase that stimulates the binding of initiator Met-tRNA(i)(Met) to the ribosomes, even in the absence of other factors [[cite:PUB00042630]]. The C-terminal domain of eukaryotic IF5 is involved in the formation of the multi-factor complex (MFC), an important intermediate for the 43S pre-initiation complex assembly [[cite:PUB00041778]]. IF5 interacts directly with IF1, IF2beta and IF3c, which together with IF2-bound Met-tRNA(i)(Met) form the MFC.</p> <p>This entry represents the zinc-binding C4 domain with a zinc-bound β-ribbon motif, which is found in IF2beta and IF5 [[cite:PUB00017012]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: