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IPR024193

Source: InterPro

Description

IPR024193 is a Ku80.

<p>This group consists of eukaryotic proteins containing the Ku80 domain. In eukaryotes it has been shown that Ku protein is involved in repairing DNA double-strand breaks by non-homologous end-joining [[cite:PUB00013573], [cite:PUB00013574], [cite:PUB00014452]]. Ku is a heterodimer of approximately 70kDa and 80kDa subunits [[cite:PUB00007947]]. Both these subunits have strong sequence similarity and it has been suggested that they may have evolved by gene duplication from a homodimeric ancestor in eukaryotes [[cite:PUB00013573]]. The prokaryotic Ku members are homodimers and they have been predicted to be involved in the DNA repair system, which is mechanistically similar to the eukaryotic non-homologous end joining [[cite:PUB00007946], [cite:PUB00013575]]. Recent findings have implicated yeast Ku in telomeric structure maintenance in addition to non-homologous end-joining [[cite:PUB00014415]]. Some of the phenotypes of Ku-knockout mice may indicate a similar role for Ku at mammalian telomeres [[cite:PUB00013576]].</p> <p>Evolutionary notes: With the currently available phyletic information it is difficult to determine the correct evolutionary trajectory of the Ku domain. It is possible that the core Ku domain was present in bacteria and archaea even before the presence of the eukaryotes. Eukaryotes might have vertically inherited the Ku-core protein from a common ancestor shared with a certain archaeal lineage or through horizontal transfer from bacteria. Alternatively, the core Ku domain could have evolved in the eukaryotic lineage and then horizontally transferred to the prokaryotes. Sequencing of additional archaeal genomes and those of early-branching eukaryotes may help resolve the evolutionary history of the Ku domain.</p> <p>Structure notes: The eukaryotic Ku heterodimer is comprised of an α/β N-terminal domain, a central β-barrel domain and a helical C-terminal arm [[cite:PUB00007947]]. Structural analysis of the Ku70/80 heterodimer bound to DNA indicates that subunit contacts lead to the formation of a highly charged channel through which the DNA passes without making any contacts with the DNA bases [[cite:PUB00007947]].</p> <p>For additional information please see [[cite:PUB00013577]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000723
Biological process Telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
Subterm of
GO:0003677
Molecular function DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
Subterm of
GO:0003684
Molecular function Damaged DNA binding Interacting selectively and non-covalently with damaged DNA.
Subterm of
GO:0005634
Cellular component Nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Subterm of
GO:0006303
Biological process Double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
Subterm of
GO:0006310
Biological process DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
Subterm of
GO:0042162
Molecular function Telomeric DNA binding Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
Subterm of
GO:0043564
Cellular component Ku70:Ku80 complex Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj3g3v2735120.1
– PREDICTED: ATP-dependent DNA helicase 2 subunit KU80-like isoform X1 [Cicer arietinum] gi|502146520|ref|XP_004506489.1|
Domains
28
LotjaGi3g1v0433200.1
– ATP-dependent DNA helicase 2 subunit KU80; TAIR: AT1G48050.1 Ku80 family protein; Swiss-Prot: sp|Q9FQ09|KU80_ARATH ATP-dependent DNA helicase 2 subunit KU80; TrEMBL-Plants: tr|G7JDE1|G7JDE1_MEDTR ATP-dependent DNA helicase 2 subunit KU80; Found in the gene: LotjaGi3g1v0433200
Domains
29
LotjaGi3g1v0433200.2
– ATP-dependent DNA helicase 2 subunit KU80; TAIR: AT1G48050.1 Ku80 family protein; Swiss-Prot: sp|Q9FQ09|KU80_ARATH ATP-dependent DNA helicase 2 subunit KU80; TrEMBL-Plants: tr|G7JDE1|G7JDE1_MEDTR ATP-dependent DNA helicase 2 subunit KU80; Found in the gene: LotjaGi3g1v0433200
Domains
29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00873 CDD 1 33.33